Results 21 to 30 of about 104,008 (312)

Polyomavirus BK-specific cellular immune response in Kidney transplant recipients [PDF]

, 2007
Polyomavirus BK is an emerging pathogen in KT recipients. New potent immunosuppressive drugs promote reactivation and replication of BKV and progression towards PVAN.
Binggeli, Simone Young
core   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Hoare, RL, Germovsek, Eva, Standing, JF, Standing, Joseph F., Lewis, J, Barker, Charlotte I.S., Lewis, Joanna, Lestner, Jodi M., Hoare, Rollo L., Barker, CI, Germovsek, E, Lestner, JM   +11 more
core   +1 more source

Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance

JCI Insight, 2022
Dominant infectious tolerance explains how brief tolerance-inducing therapies result in lifelong tolerance to donor antigens and “linked” third-party antigens, while recipient sensitization and ensuing immunological memory prevent the successful ...
Michael S. Andrade, James S. Young, Jared M. Pollard, Dengping Yin, Maria-Luisa Alegre, Anita S. Chong   +5 more
doaj   +1 more source

Helminths and immunological tolerance [PDF]

, 2014
Current immunosuppression regimens for solid-organ transplantation have shown disappointing efficacy in the prevention of chronic allograft rejection and carry unacceptable risks including toxicity, neoplasia, and life-threatening infection.
McSorley, Henry J., Maizels, Rick M., Maizels, Rick M, Johnston, Chris J C, Wigmore, Stephen J, Johnston, Chris J.C., Wigmore, Stephen J., Anderton, Stephen M, McSorley, Henry J, Anderton, Stephen M., Johnston, Chris J. C., McSorley, Henry J.; id_orcid   +11 more
core   +1 more source

Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms

JCI Insight, 2021
The programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is a potent inhibitory pathway involved in immune regulation and is a potential therapeutic target in transplantation. In this study, we show that overexpression of PD-1 on T cells (PD-
Thiago J. Borges, Naoka Murakami, Isadora T. Lape, Rodrigo B. Gassen, Kaifeng Liu, Songjie Cai, Joe Daccache, Kassem Safa, Tetsunosuke Shimizu, Shunsuke Ohori, Alison M. Paterson, Paolo Cravedi, Jamil Azzi, Peter T. Sage, Arlene H. Sharpe, Xian C. Li, Leonardo V. Riella   +16 more
doaj   +1 more source

The unfinished legacy of liver transplantation: Emphasis on immunology [PDF]

, 2006
Liver transplantation radically changed the philosophy of hepatology practice, enriched multiple areas of basic science, and had pervasive ripple effects in law, public policy, ethics, and theology.
Fadi G. Lakkis, Starzl, TE, Lakkis, FG, Thomas E. Starzl   +3 more
core   +1 more source

CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation

The Journal of Clinical Investigation, 2022
Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction.
Melissa Querrey, Stephen Chiu, Emilia Lecuona, Qiang Wu, Haiying Sun, Megan Anderson, Megan Kelly, Sowmya Ravi, Alexander V. Misharin, Daniel Kreisel, Ankit Bharat, G.R. Scott Budinger   +11 more
doaj   +1 more source

Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants

The Journal of Clinical Investigation, 2022
Solid organ transplantation is the preferred treatment for end-stage organ failure. Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts.
Isabella Pirozzolo, Martin Sepulveda, Luqiu Chen, Ying Wang, Yuk Man Lei, Zhipeng Li, Rena Li, Husain Sattar, Betty Theriault, Yasmine Belkaid, Anita S. Chong, Maria-Luisa Alegre   +11 more
doaj   +1 more source

Proceedings of the 26th Annual Virtual Congress of the International Liver Transplantation Society

, 2022
After a 1-y absence due to the coronavirus disease 2019 pandemic, the 26th Annual Congress of the International Liver Transplantation Society was held from May 15 to 18, 2021, in a virtual format.
Bhangui, Prashant, Rammohan, Ashwin, Chadha, Ryan, Nasralla, David, Alconchel, Felipe, Tanaka, Tomohiro, Yoon, Young In, KESKİN, ONUR, Mazzola, Alessandra, Liu, Jiang, Goldaracena, Nicolas, Kalisvaart, Marit, Kirchner, Varvara, Chan, Albert, Kabacam, Gokhan, Sapisochin, Gonzalo, Yoon, Young-In, Spiro, Michael, Vinaixa, Carmen, Shaker, Tamer, Campos-Varela, Isabel, De Martin, Eleonora, Yoon, Uzung, Victor, David, Hessheimer, Amelia   +24 more
core   +1 more source

Immune response in the liver under conditions of infection malignancy and transplantation

, 2014
The liver is the largest solid organ in the body and commands a large blood supply that is rich in bacterial products, environment toxins, and food antigens, which are repeatedly scanned by cells within the liver.
Mirshahidi, Saied, Kayhan, Başak, Özdamar, Şükrü Oğuz, Aharoni, Rina, Kayabaş, Üner, Padberg, Winfried   +5 more
core   +1 more source