Results 31 to 40 of about 104,008 (312)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. [PDF]

, 2013
Cytomegalovirus (CMV) continues to be one of the most common infections after solid-organ transplantation, resulting in significant morbidity, graft loss, and adverse outcomes.
Gordon, C, Nell Lurain Pediatrics: Lara Danziger Isakov, Humar, A., Zamora, M, Anders Åsberg, Nina Singh, Michaels, M., Reischig, T, Khanna, R, Harrison, J, Kumar, Deepali, Marian Michaels, David R. Snydman, Emily Blumberg, Sunwen Chou, Singh, N, BALDANTI, FAUSTO, Rajiv Khanna, Asberg, Anders, Tomas Reischig, Sester, M, Asberg A, Martin Zamora Treatment: Anders Asberg, Patricia Munoz, MichaelGreen, Rawlinson, W, Lurain, N, Asberg, A., Chou, S., Daniele Lilleri, Kotton, C.N., Danziger-Isakov, Lara, Nassim Kamar, Kotton, CN, Julian Torre Cisneros, B.e.t.s.y.C. Herold, Munoz, P, Vincent Emery, Lilleri, D, Chou, S, Snydman, DR, Graham Paget, Merville, P, Herold, BC, Humar A, Camargo, LF, Allen, U, Huprikar, S, Asberg, A, ABATE, DAVIDE ANTONIO, ChadGordon, ShirishHuprikar, Kumar, D, William Rawlinson Resistance: Sunwen Chou, Caliendo, Angela M, Green, M, Angela M. Caliendo, Humar, A, Manuel, O, Upton Allen, Danziger Isakov, L, Deepali Kumar, Kotton CN, Humar, Atul, AtulHumar Diagnostics: Angela M. Caliendo, Lattes, R, Abate, D, Kotton, Camille N, Roberta Lattes, Danziger Isakov L, Pierre Merville, Lautenschlager, I, Lara Danziger-Isakov, Fausto Baldanti, Glen Westall, Alain, S, Camille N. Kotton, Paget, G, Kumar, D., Emery, V, Martina Sester Prevention: Atul Humar, Jennifer Harrison, Mueller, N, Chou, Sunwen, Westall, G, Nicolas Mueller, Caliendo, AM, Transplantation Society International CMV Consensus Group Consensus Contributors Leaders: C.a.m.i.l.l.e.N. Kotton, Sophie Alain, Luis F. A. Camargo, Oriol Manuel, Ajit P. Limaye, Danziger-Isakov, L., Jutta Preiksaitis Immunology: Deepali Kumar, Caliendo AM, Chou S, Blumberg, E, Atul Humar, Caliendo, A.M., Preiksaitis, J, Irmeli Lautenschlager, Torre Cisneros, J, Morris, M, Kumar D, Kamar, N, Michele Morris, Limaye, AP   +105 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Studies of clinically applicable human tolerogenic dendritic cells and PD-L2 genetic modification of human islet allograft to promote graft tolerance. [PDF]

, 2011
Islet transplantation is a developing therapy for type 1 diabetic patients (T1D), which has been limited by problems associated with hypoxia, poor revascularisation and allograft rejection.
Rojas-Canales, Darling
core  

Patterning the geographies of organ transplantation: corporeality, generosity and justice

, 2006
Organ transplantation is now an established treatment for patients with end-stage organ failure, yet there are spatial inequalities in access to this procedure.
Gail Davies, Davies, G, Davies, Gail
core   +1 more source