Results 11 to 20 of about 1,385,287 (335)
The Journal of Clinical Investigation, 2022 Solid organ transplantation is the preferred treatment for end-stage organ failure. Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts.
Isabella Pirozzolo +11 more
doaj +1 more source
Skin Immunology and Rejection in VCA and Organ Transplantation
Current Transplantation Reports, 2020 Skin provides a window into the health of an individual. Using transplanted skin as a monitor can provide a powerful tool for surveillance of rejection in a transplant.
D. Leonard +4 more
semanticscholar +1 more source
NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant
JCI Insight, 2021 CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. CMV viremia often occurs in solid organ transplant recipients and associates with decreased graft survival ...
Harry Pickering +17 more
doaj +1 more source
Pediatric Clinics of North America, 1994 A major function of the immune response is the discrimination of self from nonself. It is this response that must be overcome in transplant rejection. Progress in understanding these basic immune mechanisms has helped to improve clinical outcome and lays the foundation for a new generation of therapies.
A M, Krensky, C, Clayberger
openaire +2 more sources
Clonal expansion shapes the human V\u3b41T cell receptor repertoire. [PDF]
, 2017 Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not ...
Dieli, F., Meraviglia, S.
core +1 more source
ACTH treatment promotes murine cardiac allograft acceptance
JCI Insight, 2021 Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs ...
Jing Zhao +13 more
doaj +1 more source
JCI Insight, 2021 Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell responses and the molecular components controlling them ...
Kevin Louis +14 more
doaj +1 more source
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
The Journal of Clinical Investigation, 2022 Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ...
Gaelen K. Dwyer +10 more
doaj +1 more source
The unfinished legacy of liver transplantation: Emphasis on immunology [PDF]
, 2006 Liver transplantation radically changed the philosophy of hepatology practice, enriched multiple areas of basic science, and had pervasive ripple effects in law, public policy, ethics, and theology.
Bachmann +153 more
core +1 more source
Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
JCI Insight, 2023 Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding ...
Isaac Rosado-Sánchez +8 more
doaj +1 more source