Why has immune "checkpoint" therapy failed in most clinical trials? [PDF]
Yang X, Chen L.
europepmc +1 more source
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa+4 more
wiley +1 more source
Correspondence on "METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation" by Tong <i>et al</i>. [PDF]
Pan J, Zheng GF, Rui X.
europepmc +1 more source
Passivation‐Engineered Zinc Peroxide Nanoparticles as Th1‐Biased Adjuvant for Antitumor Immunity
This study demonstrates passivated zinc peroxide nanoparticles (p‐ZPNs) as a novel class of Th1‐biased adjuvants to boost the efficacy of cancer vaccines. The p‐ZPNs exhibit excellent cellular uptake, low cytotoxicity, efficient endosome escape and intrinsic capability for triggering TLR/MyD88/NF‐κB axis, leading to robust T cell immunity.
Jiangqi Luo+9 more
wiley +1 more source
Correction: Experimental models for developing oncolytic virotherapy for metastatic prostate cancer. [PDF]
Chen YC, Figueiredo ML.
europepmc +1 more source
Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn+4 more
wiley +1 more source
A preliminary study through lymphocyte immunophenotyping of the effects of different forms of phosphorus deficiency on dairy cattle blood haematological parameters and immune status. [PDF]
Abramowicz B+3 more
europepmc +1 more source
Identification of conserved T cell epitopes and flanking amino acid mutants of endogenous retrovirus Gag antigen in nonobese diabetic mice. [PDF]
Dai YD, Li S, Margosiak A, Hu WY.
europepmc +1 more source
Identification and validation of tissue-based gene biomarkers for acute intestinal graft-versus-host disease(AIGVHD). [PDF]
Chen H, Fu L, Liu L, He Y.
europepmc +1 more source