Results 91 to 100 of about 18,790,944 (322)

Two polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteins

, 2014
Major histocompatibility complex class I molecules (MHC I) present peptides to cytotoxic T-cells at the surface of almost all nucleated cells. The function of MHC I molecules is to select high affinity peptides from a large intracellular pool and they ...
van Hateren, Andy, Elliott, Tim, Tim Elliott (201327), Alistair Bailey, Jörn M Werner, Bailey, Alistair, Werner, Jörn M., Tim Elliott, Jörn M. Werner (524999), Andy van Hateren, Alistair Bailey (524997), Andy van Hateren (524998), Werner Jörn M., van Hateren Andy, Elliott Tim, Bailey Alistair   +15 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Allele Frequency Analysis of HLA-A, -B, -DRB1, -DQA1, and -DQB1 Using LABTypeTM SSO in a Patient Cohort from Jeonbuk National University Hospital

Korean Journal of Clinical Laboratory Science
This retrospective, single-center study analyzed the distribution and frequency of HLA alleles in 238 patients who visited or were admitted to Jeonbuk National University Hospital between January 2023 and March 2024 and underwent HLA genotyping.
Ji Young MUN, Joonhong PARK
doaj   +1 more source

Table2_Current status and perspectives of the quality system in histocompatibility laboratories in Poland.docx

Allogeneic transplantation is a multi-step process involving many clinicians and laboratory personnel working together to achieve a common goal—to maximize the recipients’ chance of survival and to improve their quality of life.
Katarzyna Bogunia-Kubik (680178), Monika Baj-Krzyworzeka (15832685), Barbara Piątosa (13186551), Izabela Uhrynowska-Tyszkiewicz (17848817)   +3 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing

Clinical Transplantation and Research
Human leukocyte antigen (HLA) is a group of glycoproteins encoded by the major histocompatibility complex (MHC) that plays a pivotal role in the host's immune defense.
Haeyoun Choi, Eun-Jeong Choi, Hyoung-Jae Kim, In-Cheol Baek, Aegyeong Won, Su Jin Park, Tai-Gyu Kim, Yeun-Jun Chung   +7 more
doaj   +1 more source

HISTOCOMPATIBILITY SYSTEM IN RENAL TRANSPLANTATION [PDF]

, 2016
The paper presents a contemporary view on organization of genes in the major histocompatibility complex, their protein products, and nomenclature of human leukocyte ...
O. N. Jakovchik, A. V. Vatazin, N. G. Dmitrieva, A. B. Zul’karnaev, V. A. Fedulkina   +4 more
core   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Acute High Intensity Interval Exercise Promotes Circulating Progenitor Cell Mobilization and Improves Microcirculation in Patients with Chronic Heart Failure

Journal of Cardiovascular Development and Disease
Endothelial progenitor cells (EPCs) constitute a cell population that enters the circulation during aerobic exercise and facilitates vascular function.
Georgios Mitsiou, Savvas P. Tokmakidis, Irini Patsaki, Katherina Psarra, Christos Kourek, Eleftherios Karatzanos, George Papathanasiou, Stavros Dimopoulos   +7 more
doaj   +1 more source

Sequence of the mouse Q4 class I gene and characterization of the gene product [PDF]

, 1988
The Q4 class I gene has been shown to participate in gene conversion events within the mouse major histocompatibility complex. Its complete genomic nucleotide sequence has been determined.
Robinson, Peter J., Bevec, Dorian, Mellor, Andrew L., Weiss, Elisabeth H.   +3 more
core   +1 more source