Results 221 to 230 of about 18,790,944 (322)

Identification of the Novel HLA-DQB1*06:556 Allele by Next-Generation Sequencing. [PDF]

HLA
Du Z, Sudario MEA, Cussen K, Elrefaei M.
europepmc   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Characterisation of a New HLA Allele by Next-Generation Sequencing: HLA-C*06:424Q. [PDF]

HLA
Balakrishnan G, Shankar K, Vetriselvan R, Raut P, Agarwal N.   +4 more
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Characterisation of the Novel HLA-B*51:01:01:126 Allele in a Greek Renal Transplant Candidate. [PDF]

HLA
Kouniaki D, Nikolaou S, Tsirogianni A.
europepmc   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

The Novel HLA-C*01:02:01:78 Allele Identified in a Greek Haematopoietic Stem Cell Donor. [PDF]

HLA
Kouniaki D, Kitsiou V, Tsirogianni A.
europepmc   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Non-HLA Antibody-Associated Hyperacute Allograft Rejection Following Lung Transplantation. [PDF]

Pediatr Transplant
Karolak JA, Melicoff E, Varghese NP, Szafranski P, Bölükbaşı EY, McHugh EE, Nicholas S, Jindra P, Hicks J, Austin ED, Stankiewicz P, Mallory GB.   +11 more
europepmc   +1 more source