Results 71 to 80 of about 451,287 (334)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

PARTICULARITIES OF THE MANAGEMENT OF THE HISTOLOGY LABORATORY [PDF]

Annals of the University of Craiova: Economic Sciences Series, 2019
The managerial process in the health field is an extremely complex one, because it presents besides the basic components of an organizational system and the human component: the patient.
Oprea-Valentin BUSU , Cristina-Elena ANDREI   +1 more
doaj  

Ecotoxicological consequences of heavy metals on emperor fish (lethrinus) species in the red sea: histopathology and biochemistry [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Heavy metal (HMs) contamination in marine environments is a global concern, affecting fish health and seafood safety. This study examined the effects of HMs on 90 emperor fish from the Red Sea, focusing on metal levels in water and fish liver, blood ...
Soha A. ALSOLMY, Raoum MOMINKHAN, Sahar J. MELEBARY   +2 more
doaj   +1 more source

Primary biliary cirrhosis and hepatic sarcoidosis: A case report [PDF]

Vojnosanitetski Pregled, 2014
Introduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic progressive inflammatory liver disease leading to destruction of small interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown etiology characterized by non-
Alempijević Tamara, Sokić-Milutinović Aleksandra, Tončev Ljubiša, Pavlović-Marković Aleksandra, Đuranović Srđan, Tomanović Nada, Drulović Jelena   +6 more
doaj   +1 more source

Comparison of osseointegration in piezoimplants versus cylindrical implants [PDF]

, 2019
BACKGROUND: Dental implants have been successful for the restoration of edentulous areas, but current techniques are inadequate in areas lacking sufficient bone volume. Piezoelectric surgery has shown encouraging effects on both osseous healing.
Fujinaka, Trevor
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Malignant fibrous histiocytoma of the right upper leg: A case report [PDF]

Vojnosanitetski Pregled, 2018
Introduction. Malignant fibrous histiocytoma is a fast spreading pleomorphic sarcoma with a high malignant potential. Its spreading is characterized with local invasion and distant metastazes with early onset. Most common localisations of development are
Pavlović Mladen, Milošević Bojan, Radovanović Dragče, Cvetković Aleksandar, Trifunović Bratislav, Čanović Dragan, Mitrović Slobodanka, Jovanović Milan, Spasić Marko, Vulović Maja, Stojanović Bojan, Jeremić Dejan, Jevđić jasna   +12 more
doaj   +1 more source

Comparative analysis of spatial and transform domain methods for meningioma subtype classification [PDF]

, 2010
Pattern recognition in histopathological image analysis requires new techniques and methods. Various techniques have been presented and some state of the art techniques have been applied to complex textural data in histological images.
Qureshi, Hammad A., Rajpoot, Nasir M. (Nasir Mahmood)   +1 more
core  

Early markers of angiogenesis and ischemia during bowel conduit neovascularization [PDF]

, 2017
Background Bowel flaps are a good and reliable method to restore the continuity of the aerodigestive tract. Radiated fields, contaminated recipient sites, or depleted recipient vessels may increase the risk for ischemic injury after transfer.
Chen, Hung-chi, Chen, Pei-yu, Ciudad, Pedro, Li, Yun-fen, Lo Torto, Federico, Manrique, Oscar J., Nguyen, Doan-minh, Wong, Alex   +7 more
core   +1 more source