Results 71 to 80 of about 89,446 (248)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

TUBARIAL ORGAN-LIKE GLANDULAR TISSUE – A COMPARATIVE HISTOLOGY STUDY IN HUMANS AND CANINES [PDF]

Journal of IMAB
Purpose: A "new organ at risk" with characteristics of glandular tissue above the torus tubarius has been accidentally reported on PSMA PET/CT. Based on its location, that "finding" was named "tubarial (salivary) glands".
Bistra Blagova, Lyubomir Hristakiev, Lina Malinova   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

THE FORMATION OF HISTOLOGY AS AN INDEPENDENT SCIENTIFIC DISCIPLINE ON MEDICAL FACULTY OF THE IMPERIAL MOSCOW UNIVERSITY IN THE MIDDLE OF XIX CENTURY (1860–1891)

Сеченовский вестник, 2012
The paper gives a brief outline of the institutional and cognitive structure of university education and science in Russia as an example of the morphological sciences at the medical faculty of the Imperial Moscow University.
S. L. Kuznetsov, C. S. Ghadzhieva
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Protective Effects of the Essence and Aqueous Extract of Achillea millefolium and Vitamin E on Atrazine-induced Follicular Atresia in Rats

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Atrazine causes some biological effects including atresia in ovarian folicules. Essense and aqueous extract of Achillea milifolium and vitamin E are important due to prevention of atresia.
Shapour Hasanzadeh, Raana Esmaeily Maleki, Farzaneh Bonyadi   +2 more
doaj  

Comparative analysis of human Mesenchymal Stromal Cells from Adipose Tissue and Dental Pulp: phenotypic characterization and secretome profiling

Biology Direct
Background In tissue regeneration, as well as in post-traumatic recovery or in treating pathological alterations, mesenchymal stromal cells (MSCs) and their products for cell-free treatments are increasingly attractive and applicable.
Alessia Ventura, Antonio Libonati, Serena Marcozzi, Maria Assunta Ucci, Giulia Salvatore, Andrea Galgani, Stefano Pirrò, Micol Massimiani, Mario Picozza, Rosita Russo, Simone Vumbaca, Donatella Farini, Angela Chambery, Giovanna Borsellino, Massimo De Felici, Francesca Gioia Klinger, Vincenzo Campanella, Antonella Camaioni   +17 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

PCOS women show significantly higher homocysteine level, independent to glucose and E2 level

Iranian Journal of Reproductive Medicine, 2016
Background: It is reasonable to think that some biochemical characteristics of follicular fluid (FF) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and ...
Zahra Eskandari, Rajab-Ali Sadrkhanlou, Vahid Nejati, Gholamreza Tizro   +3 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source