Results 61 to 70 of about 1,714,596 (353)

Classification of Breast Cancer Histology Images Using Multi-Size and Discriminative Patches Based on Deep Learning

IEEE Access, 2019
The diagnosis of breast cancer histology images with hematoxylin and eosin stained is non-trivial, labor-intensive and often leads to a disagreement between pathologists.
Yuqian Li, Junmin Wu, Qisong Wu
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Microscopy with ultraviolet surface excitation for rapid slide-free histology

Nature Biomedical Engineering, 2017
Histological examination of tissues is central to the diagnosis and management of neoplasms and many other diseases and is a foundational technique for preclinical and basic research.
F. Fereidouni, Zachary T. Harmany, M. Tian, A. Todd, John A. Kintner, J. McPherson, A. Borowsky, J. Bishop, M. Lechpammer, S. Demos, R. Levenson   +10 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effect of Sodium Selenite and Zinc Sulphate on the Weight, Size, Seminal Fluid Traits, and Histological Changes of the Testis and Epididymis in Kurdi Rams

Indonesian Journal of Innovation and Applied Sciences
This study was conducted to investigate the effects of Sodium selenite (Se) and zinc sulfate (Zn) supplementation individually and blended between them on semen quality, testicle size, weight, and Histological changes of the testis and epididymis, in 12 ...
Zirak M. R. Palani, Khalil, W.A, Hamid E. I. Kutaibani, Faraidoon A. M. Amin   +3 more
doaj   +1 more source

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy

Science Advances, 2017
A photoacoustic microscope system provides label-free multilayered histology-like imaging of unprocessed human breast specimens. The goal of breast-conserving surgery is to completely remove all of the cancer.
T. T. Wong, Ruiying Zhang, Pengfei Hai, Chi Zhang, Miguel A. Pleitez, R. Aft, D. Novack, Lihong V. Wang   +7 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Study of Sperm Parameters and Sperm Fertility in Mice were Exposed to Tamoxifen during Embryonic Development

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2017
Introduction: Tamoxifen is steroidal drug, which mainly treats breast cancer and also used to stimulate ovulation. The purpose of the present study was the evaluation of sperm parameters and fertility of mice whose mothers had received tamoxifen during ...
J Soleimanirad, l Roshangar, M Abouzaripour, E Daneshi   +3 more
doaj  

Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies

American Journal of Transplantation, 2019
Discrepancy analysis comparing two diagnostic platforms offers potential insights into both without assuming either is always correct. Having optimized the Molecular Microscope Diagnostic System (MMDx) in renal transplant biopsies, we studied ...
K. Madill‐Thomsen, A. Perkowska-Ptasińska, G. Böhmig, F. Eskandary, G. Einecke, G. Gupta, P. Halloran   +6 more
semanticscholar   +1 more source