Results 61 to 70 of about 794,415 (316)

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim   +11 more
wiley   +1 more source

The evolving understanding of histology as an endpoint in ulcerative colitis [PDF]

open access: yesIntestinal Research
A therapeutic goal for patients with ulcerative colitis (UC) is deep remission including clinical remission and mucosal healing. Mucosal healing was previously defined by endoscopic appearance, but recent studies demonstrate that histological ...
Shintaro Akiyama   +2 more
doaj   +1 more source

Treatment of low-grade gastric malt lymphoma using Helicobacter pylori eradication [PDF]

open access: yesVojnosanitetski Pregled, 2015
Background/Aim. Lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the stomach usually occurs as a consequence of Helicobacter pylori (H. pylori) infection. The aim of this study was to investigate the long-term effect of treatment
Grgov Saša   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Impact of dental implant insertion method on the periimplant epithelial seal: Experimental study on dogs [PDF]

open access: yesVojnosanitetski Pregled, 2010
Background/Aim. There is a controversial opinion among implantologists on the method of dental implantation that provides more favourable response of soft and bone tissues.
Matić Smiljana   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The human trapezio-metacarpal joint : an anatomical, osteometric and clinical study [PDF]

open access: yes, 1981
Thesis (M.Sc.) -- University of Adelaide, Dept.
Trott, Patricia Helen
core  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

OBSERVATIONS ON RECEPTORS IN THE MUSCULAR TISSUE OF HEGU AND YONGQUAN POINTS

open access: yes针刺研究, 1980
1.Receptors in the muscular tissue of 4 Hegu and 3 Yungquan points were studied by the methods of Bielschowsky and Faworsky.The following four kinds of receptors were revealed:(1)Free nerve endings attached onto the surface of muscle fibers and ending ...
Wang Zhongtao Wu Shulan Cao Yuchun Department of Histology and Embryology of Hebei Medical College
doaj   +2 more sources

GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway

open access: yesInternational Journal of Clinical Practice
Background. Amino acid metabolism, including ATP production, nucleotide synthesis, and redox homeostatic processes, are associated with proliferation and differentiation of tumor cells.
Yaowen Zhang   +5 more
doaj   +1 more source

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