Results 371 to 380 of about 844,749 (403)
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Life Sciences, 1974
Abstract The biological roles of the histones are multiple; by complexing to DNA they cause such DNA to be inactive as a template for RNA polymerase; they cause supercoiling of the DNA which would appear to be a fundamental requirement for further orders of supercoiling, presumable exemplified by metaphase chromosomes; a particular histone even forms
James Bonner, William T. Garrard
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Abstract The biological roles of the histones are multiple; by complexing to DNA they cause such DNA to be inactive as a template for RNA polymerase; they cause supercoiling of the DNA which would appear to be a fundamental requirement for further orders of supercoiling, presumable exemplified by metaphase chromosomes; a particular histone even forms
James Bonner, William T. Garrard
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Biochimica et Biophysica Acta, 1957
Abstract A study of the effect of dialysis on histone preparations obtained from calf thymus nucleoprotein by different methods showed that amount and characteristics of dialyzable material vary with the mode of preparation and the pH of the dialyzing medium. A modified assembly for fractional dialysis is described.
Bohdan Bakay +2 more
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Abstract A study of the effect of dialysis on histone preparations obtained from calf thymus nucleoprotein by different methods showed that amount and characteristics of dialyzable material vary with the mode of preparation and the pH of the dialyzing medium. A modified assembly for fractional dialysis is described.
Bohdan Bakay +2 more
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Histones and Their Modification
Critical Reviews in Biochemistry, 1986Histones constitute the protein core around which DNA is coiled to form the basic structural unit of the chromosome known as the nucleosome. Because of the large amount of new histone needed during chromosome replication, the synthesis of histone and DNA is regulated in a complex manner.
Roy S. Wu +3 more
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Experimental Cell Research, 1967
Abstract The meiotic cells in the anthers of lily and tulip contain a unique histone which is absent or nearly so, from the somatic tissues of these plants. This histone, termed the meiotic histone, is synthesized during the premeiotic histone synthesis, persists through meiosis, microsporogenesis, and pollen maturation.
W.F. Sheridan, H. Stern
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Abstract The meiotic cells in the anthers of lily and tulip contain a unique histone which is absent or nearly so, from the somatic tissues of these plants. This histone, termed the meiotic histone, is synthesized during the premeiotic histone synthesis, persists through meiosis, microsporogenesis, and pollen maturation.
W.F. Sheridan, H. Stern
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BioEssays, 1985
AbstractHistones occur in equal amounts to DNA in the cell nucleus and are largely responsible for the compaction of the genome into chromatin via the formation of nucleosomes and higher‐order structures. Whereas two of the five histone types exhibit little structural variation, the remaining three occur in many variant tissue‐ or species‐specific ...
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AbstractHistones occur in equal amounts to DNA in the cell nucleus and are largely responsible for the compaction of the genome into chromatin via the formation of nucleosomes and higher‐order structures. Whereas two of the five histone types exhibit little structural variation, the remaining three occur in many variant tissue‐ or species‐specific ...
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Histone post-translational modifications — cause and consequence of genome function
Nature reviews genetics, 2022Gonzalo Millán-Zambrano +3 more
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Histone variants and histone modifications: A structural perspective
Biochemistry and Cell Biology, 2001In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role.
D. Wade Abbott +3 more
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Modulation of cellular processes by histone and non-histone protein acetylation
Nature reviews. Molecular cell biology, 2022M. Shvedunova, A. Akhtar
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Histone Acetylation and Histone Deacetylation
2003In the resting cell, DNA is tightly compacted to prevent transcription factor accessibility. During activation of the cell, this compact inaccessible DNA is made available to DNA-binding proteins, thus allowing the induction of gene transcription (1 ,2). DNA is packaged into chromatin, a highly organized and dynamic protein-DNA complex. The fundamental
Peter J. Barnes +2 more
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2008
Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
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Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
openaire +3 more sources