Results 291 to 300 of about 137,192 (357)

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a. [PDF]

Front Pharmacol
Samuvel DJ, Lemasters JJ, Chou CJ, Zhong Z.   +3 more
europepmc   +1 more source

Deacetylase inhibitors - focus on non-histone targets and effects

, 2010
Matthias Ocker
openalex   +2 more sources

The role of constitutive nitric‐oxide synthase in regulation of IKKα after ultraviolet irradiation

Photochemistry and Photobiology, EarlyView.
cNOS enhances IKKα expression following UVB exposure by promoting promoter activation, transcriptional elongation, and Ets‐1 stabilization. These actions sustain IKKα levels, reduce UV‐induced skin carcinogenesis, and highlight cNOS as a key protective factor against solar UV damage.
Yuxi Zhou, Lingying Tong, Bernardo Bastidas, Tao Liu, Madison Wright, Muxiang Zhou, Shiyong Wu   +6 more
wiley   +1 more source

Histone deacetylase inhibitor boosts anticancer potential of fusogenic oncolytic vaccinia virus by enhancing cell-cell fusion. [PDF]

Cancer Sci
Nakatake M, Kurosaki H, Nakamura T.
europepmc   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations. [PDF]

Acta Pharmacol Sin
Hao BB, Ma K, Xu JY, Fan RF, Zhao WS, Jia XL, Zhai LH, Lee S, Xie D, Tan MJ.   +9 more
europepmc   +1 more source

Supplemental Table S2 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Robert W. Robey, Christina M. Fitzsimmons, Wilfried M. Guiblet, William J.E. Frye, José M. González Dalmasy, Li Wang, Drake A. Russell, Lyn M. Huff, Andrew J. Perciaccante, Fatima Ali-Rahmani, Crystal C. Lipsey, Heidi M. Wade, Allison V. Mitchell, Siddhardha S. Maligireddy, David Terrero, Donna Butcher, Elijah F. Edmondson, Lisa M. Jenkins, Tatiana Nikitina, Victor B. Zhurkin, Amit K. Tiwari, Anthony D. Piscopio, Rheem A. Totah, Susan E. Bates, H. Efsun Arda, Michael M. Gottesman, Pedro J. Batista   +26 more
openalex   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, EarlyView.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source