Biochemistry and occurrence of O-demethylation in plant metabolism
Frontiers in Physiology, 2010 Demethylases play a pivitol role in numerous biological processes from covalent histone modification and DNA repair to specialized metabolism in plants and microorganisms.
Jillian Hagel, Peter Facchini
doaj +1 more source
Cancer Science, EarlyView.The antitumor immune response is attenuated in T cell‐specific Ezh2 knockout mice. ABSTRACT Appropriate regulation of the differentiation balance between effector CD8+ T cells and memory CD8+ T cells is crucial for an appropriate immune response. We previously reported that the tumor suppressor menin suppresses the differentiation of CD8+ T cells into ...
Kenji Takagi +5 more
wiley +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Analytical Cellular Pathology, 2018 Over the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications.
Anubhav Chakraborty +1 more
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Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation. [PDF]
J Biol Chem, 2022 Martinez CA +8 more
europepmc +1 more source
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, EarlyView.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
Genome Biology, 2018 Background Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem
Özgen Deniz +4 more
doaj +1 more source
KDM6A missense variants hamper H3 histone demethylation in lung squamous cell carcinoma. [PDF]
Comput Struct Biotechnol J, 2022 Biagini T +9 more
europepmc +1 more source
Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells
The FEBS Journal, EarlyView.MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe +5 more
wiley +1 more source
KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. [PDF]
Theranostics, 2021 Jiang Y +9 more
europepmc +1 more source