Results 301 to 310 of about 394,873 (373)

Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction. [PDF]

Eur J Clin Invest
Allawa L, Poirier A, Pignon P, Beaumont J, Lebeau L, Barbelivien A, Bochaton T, Beauvillain C, Henrion D, Delneste Y, Jeannin P, Prunier F, Tamareille S.   +12 more
europepmc   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source

CREB binding protein (CREBBP): Structure-based perspectives for the development of clinical inhibitors. [PDF]

Transl Oncol
Liu R, Li J, Nian Q, Tu G, Wang Z, Zhang R, Li G.   +6 more
europepmc   +1 more source

THE INTERACTION OF RNA POLYMERASE WITH HISTONES

, 1969
Thomas C. Spelsberg, Sharon Tankersley, Lubomir S. Hnilica   +2 more
openalex   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Biomolecular tracking by FIRESCAPE reveals distinct modes of clearance, damage induction and cellular uptake for extracellular histone H3

Josephson B, Poh AWJ, Demyanenko Y, Yates AG, Ford J, Giltrap AM, Auchynnikava T, Tan KV, Dunstan IK, Liu W, Cribbs AP, Wang C, Philpott M, Able S, Sap JBI, Bedwell A, Aarnio R, Dickens AM, Helin JS, Kovacs L, Rajala NA, Miner MWG, Oppermann U, Vallis KA, McGowan DR, Airaksinen AJ, Gouverneur V, Mohammed S, Anthony DC, Davis BG.   +29 more
europepmc   +1 more source

Identification of novel H2A histone variants across diverse clades of algae. [PDF]

Genome Biol
Rousselot E, Nehr Z, Aury JM, Denoeud F, Cock JM, Tirichine L, Duc C.   +6 more
europepmc   +1 more source

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, EarlyView.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Glutamate Methylation, a Novel Histone Mark in Diatoms: Mass Spectrometry Identification and Structural Characterization. [PDF]

Plant Direct
Téletchéa S, Lombard B, Hendrickx J, Loew D, Tirichine L.   +4 more
europepmc   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source