Results 131 to 140 of about 202,762 (305)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease.

, 2013
Mycobacterium ulcerans infection causes a neglected tropical disease known as Buruli ulcer that is now found in poor rural areas of West Africa in numbers that sometimes exceed those reported for another significant mycobacterial disease, leprosy, caused
Jacques H Grosset, Deepak V Almeida, Robinson, C, Sarfo, FS, Jihui Zhang, Almeida, DV, Paul J Converse, Clive Robinson, Wansbrough-Jones, M, Mark Wansbrough-Jones, Grosset, JH, Fred Stephen Sarfo, Converse, PJ, Zhang, J   +13 more
core   +1 more source

MFF-ClassificationNet: CNN-Transformer Hybrid with Multi-Feature Fusion for Breast Cancer Histopathology Classification

Biosensors
Breast cancer is one of the most prevalent malignant tumors among women worldwide, underscoring the urgent need for early and accurate diagnosis to reduce mortality.
Xiaoli Wang, Guowei Wang, Luhan Li, Hua Zou, Junpeng Cui   +4 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Hyperchromatic nucleus segmentation on breast histopathological images for mitosis detection

, 2018
Breast cancer grading is the standard clinical practice for the prognosis and diagnosis of breast cancer development. The Nottingham Histological Grading (NHG) system is widely used in the breast cancer grading.
Nur Asiha Binti Sazali 2
core   +1 more source

Attention-aided hybrid transformer network for oral squamous cell carcinoma classification using histopathology images

Frontiers in Artificial Intelligence
IntroductionIn recent years, oral cancer has become one of the most common malignant tumors. Early diagnosis of oral cancer from histopathological images will certainly reduce the severity of the disease and bring down the death rate.
Meena Jagathesh, Sathiya Narayanan
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Radiograph and histopathological images of a 31-year-old female diagnosed with left hip PVNS.

, 2015
Radiograph and histopathological images of a 31-year-old female diagnosed with left hip PVNS.
Rui-zhen Qi (709159), Bin Yu (14464), Jian-chun Zeng (709157), Qian Xu (119888), Chang-xiang Liang (709156), Zhi-yuan Chen (709158), Nan Jiang (21252), Guo-ping Xie (709155), Yi-rong Chen (5662630)   +8 more
core   +1 more source

A Transparent Search-Based Framework for Skin and Breast Cancer Diagnosis Using Siamese Networks

IEEE Access
Computer aid diagnosis has developed digital pathology with Deep Learning (DL)-based tools to assist pathologists in decision-making. Content-Based Histopathological Image Retrieval (CBHIR) is a novel tool to seek highly correlated patches in terms of ...
Zahra Tabatabaei, Adrian Colomer, Javier Oliver Moll, Valery Naranjo   +3 more
doaj   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source