Results 61 to 70 of about 2,410 (213)

Attention-Based DenseNet for Lung Cancer Classification Using CT Scan and Histopathological Images

Designs
Lung cancer is identified by the uncontrolled proliferation of cells in lung tissues. The timely detection of malignant cells in the lungs, crucial for processes such as oxygen provision and carbon dioxide elimination in the human body, is imperative ...
Jia Uddin
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Robust Method for the Unsupervised Scoring of Immunohistochemical Staining

Entropy
Immunohistochemistry is a powerful technique that is widely used in biomedical research and clinics; it allows one to determine the expression levels of some proteins of interest in tissue samples using color intensity due to the expression of biomarkers
Iván Durán-Díaz, Auxiliadora Sarmiento, Irene Fondón, Clément Bodineau, Mercedes Tomé, Raúl V. Durán   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Color Normalization in Breast Cancer Immunohistochemistry Images Based on Sparse Stain Separation and Self-Sparse Fuzzy Clustering

Diagnostics
Background and Objective: The color normalization of breast cancer immunohistochemistry (IHC)-stained images helps change the color distribution of undesirable IHC-stained images to be more interpretable for the pathologists.
Attasuntorn Traisuwan, Somchai Limsiroratana, Pornchai Phukpattaranont, Phiraphat Sutthimat, Pichaya Tandayya   +4 more
doaj   +1 more source

Digital Histopathology by Infrared Spectroscopic Imaging

Annual Review of Analytical Chemistry, 2023
Infrared (IR) spectroscopic imaging records spatially resolved molecular vibrational spectra, enabling a comprehensive measurement of the chemical makeup and heterogeneity of biological tissues. Combining this novel contrast mechanism in microscopy with the use of artificial intelligence can transform the practice of histopathology, which currently ...
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A multi-task deep learning framework for simultaneous prediction of microsatellite instability and tumor mutational burden in gastric cancer from histopathological images

Frontiers in Oncology
BackgroundThe clinical management of gastric cancer (GC) increasingly relies on the biomarkers microsatellite instability (MSI) and tumor mutation burden (TMB) to identify patients likely to benefit from immunotherapy.
Yazhou Chang, Haoyue Chang, Yaping Lv, Shuxue Xi, Jialiang Yang, Jialiang Yang, Bingzhi Wang, Xiaohao Zheng, Yibin Xie   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Enhancing Early Detection of Oral Squamous Cell Carcinoma: A Deep Learning Approach with LRT-Enhanced EfficientNet-B3 for Accurate and Efficient Histopathological Diagnosis

Diagnostics
Background/Objectives: Oral cancer, particularly oral squamous cell carcinoma (OSCC), ranks as the sixth most prevalent cancer globally, with rates of occurrence on the rise.
A. A. Abd El-Aziz, Mahmood A. Mahmood, Sameh Abd El-Ghany   +2 more
doaj   +1 more source