Results 111 to 120 of about 34,682 (317)

Marges van de bouwhistorie

open access: yesBulletin KNOB, 2010
Although a considerable percentage of the practising building historians have an academic background, the origin of building history lies in the practical preservation of monuments and historic buildings.
Ronald Stenvert
doaj   +1 more source

Nursing research: historical background and teaching information strategies.

open access: yesBulletin of the Medical Library Association, 1986
The expansion of research-based literature is one of the foremost goals of the nursing profession. Linked to this goal are the utilization and further development of nursing libraries. This paper discusses some historical factors that have influenced nursing literature. It presents a model for teaching graduate nursing students the relationship between
J M, Sarkis, V L, Conners
openaire   +1 more source

Second Language Acquisition: A Framework and Historical Background on Its Research

open access: yesEnglish Language Teaching, 2020
Research shows many problems and ambiguities of second language acquisition (SLA), which have made learners and readers worldwide unsatisfied. Therefore, this study attempts to highlight theories and research that have comprehensive explanations of the problems and ambiguities of second language acquisition, which learners of English as a Foreign ...
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Complete Immunophenotypic Reversal of Chronic Lymphocytic Leukaemia With High Dose Parenteral Methylcobalamin: A Case Report and Brief Review of Cobalamin in Cancer

open access: yesCancer Reports
Background Supposed ‘spontaneous’ remissions in chronic lymphocytic leukaemia (CLL) are extremely rare. By the most stringent immunophenotypic criteria, there are only seven cases to date of unexplained, immune system effected cures. A historic review of
Carmen Wheatley
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Best Practices for Historic Masonry Repair and Rehabilitation [PDF]

open access: yes
The most recently published update of the Virginia Department of Transportation\u2019s (VDOT\u2019s) historic bridge management plan, A Management Plan for Historic Bridges in Virginia: The 2017 Update, noted a number of special considerations regarding ...
Miller, Ann B.   +1 more
core  

Digging Deeper: The influence of historic mining on Glasgow's subsurface thermal state to inform geothermal research

open access: yes, 2019
Background information on the chronology of historic mining at each borehole location and a summary of groundwater flow in mine workings beneath ...
Neil M. Burnside (7438661)   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Living history with Open Virtual Worlds : Reconstructing St Andrews Cathedral as a stage for historic narrative

open access: yes, 2012
St Andrews Cathedral is located on the East Coast of Scotland, construction started in 1160 and spanned Romanesque and Gothic architectural styles. It was consecrated in 1318, four years after the battle of Bannockburn in the presence of King Robert the ...
Miller, Alan Henry David   +11 more
core  

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