Results 131 to 140 of about 218,779 (308)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A Survey of Historic Caddo Sites in Nacogdoches County, Texas [PDF]
, 2007 This review was originally prepared for presentation to the East Texas Caddo Research Group held in Nacogdoches, Texas on December 2 and 3, 2006. The primary purpose of this article is to summarize the archaeological resources currently known relating to
Middlebrook, Tom
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Diferents, 2017 El Museu del Disseny de Barcelona és un museu de les arts de l’objecte i el disseny, que reuneix les col·leccions dels antics museus de les Arts Decoratives, Ceràmica, Tèxtil i d’Indumentària i de les Arts Gràfiques, sota un nou projecte museològic comú ...
Pilar Vélez
doaj
IMLS PLACE Grant: Campus Journal Press Release [PDF]
, 2013 Campus Journal press release describing the PLACE (Position-based Location Archive Coordinate Explorer) project that is funded by the Institute for Museum and Library Services.
PLACE Project Group
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A Tradition of Bells: Glatfelter Bell and Hall
, 2018 Every hour, students and staff hear the tolling of a bell. Some students hear it and count the number of times it rings to see what time it is. Others hear it and realize they are late to class.
Zeltmann, Shannon R.
core
Raman spectroscopy, a non-destructive solution to the study of glass and its alteration [PDF]
, 2008 This paper presents the potential of Raman spectroscopy, a non-destructive technique which can be applied in-situ, for the analyses of glass and their alteration. Recent analytical developments are summarised for different glass composition and practical
Bouquillon, A +6 more
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source