Results 81 to 90 of about 248,895 (305)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Energy Retrofit of Heritage Buildings Through Photovoltaic and Community Energy Approaches: A Case Study Analysis

Buildings
The building sector accounts for nearly 40% of total energy consumption in Europe, with heritage buildings posing a critical challenge due to conservation constraints.
Daniele Vitella, Leone Barbaro, Emanuele de Lieto Vollaro, Gabriele Battista   +3 more
doaj   +1 more source

Quantification of Humidity and Salt Detection in Historical Building Materials via Broadband Radar Measurement. [PDF]

Sensors (Basel), 2023
Blaschke O, Brand F, Drese KS.
europepmc   +1 more source

Exterior View of the Illinois Building Entrance

, 2000
In 2006 Historic Landmarks Foundation of Indiana placed the Illinois Building on its 10 Most Endangered list. The structure is still sound. "The threat: An empty ten-story building in the heart of a thriving downtown triggers preservation alarms."Appears
Indiana Historical Society
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Comparison of Temperature Profiles of Aged and Fresh Larch Timber Beams Exposed to Radiant Heat Source

Buildings
Historic timber buildings rely heavily on naturally aged wood. However, the influence of long-term environmental exposure on the thermal behavior and fire performance of such structural members remains insufficiently understood.
Dominik Špilák, Andrea Majlingova
doaj   +1 more source

An Approach to the Use of Glycol Alkoxysilane-Polysaccharide Hybrids in the Conservation of Historical Building Stones. [PDF]

Molecules, 2021
Meléndez-Zamudio M, Bravo-Flores I, Ramírez-Oliva E, Guerra-Contreras A, Álvarez-Guzmán G, Zárraga-Nuñez R, Villegas A, Martínez-Rosales M, Cervantes J.   +8 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Multivariate Characterization of Temperature Fluctuations in a Historical Building Using Energy-Efficient IoT Wireless Sensors. [PDF]

Sensors (Basel), 2021
Zarzo M, Perles A, Mercado R, García-Diego FJ.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source