Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Concept of Constitution in the History of Political Thought
Intro -- Contents -- Editors' Note and Acknowledgments -- 1 The Ambiguity of Constitutionalism -- 2 Epistemology of Constitution -- 3 Can the Constitution Do Away with Nation State? -- 4 Remarks on the Legal and the Practical: The Rechtsstaat in Europe's
Szlachta, Bogdan. +1 more
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The 1977 Soviet Constitution: A Historical Comparison
, 1979 Throughout the Soviet Union\u27s history, its four constitutions have been a reflection of the political climate of the particular period. The documents thus viewed provide a historical and political benchmark against which life and thought in the U.S.S ...
Christian, Gary I., Kavass, Igor L.
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Tuberculosis in Tibetan refugee settlements in India: a human rights perspective. [PDF]
Front Public HealthYanga N +4 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The U.S. Constitution and Monetary Powers: An Analysis of the 1787 Constitutional Convention and Constitutional Transformation of the Nation's Monetary System Emerged [PDF]
The monetary powers embedded in the U.S. Constitution were revolutionary and led to a watershed transformation in the nation's monetary structure. They included determining what monies could be legal tender, who could emit fiat paper money, and who could
Farley Grubb
core
Beyond reproductive rights: implementing the Africentric reproductive justice framework in sexual and reproductive health and rights litigations in Africa. [PDF]
Sex Reprod Health MattersMulumba M, Oga J, Muhumuza N.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Guide to the Commission on the Bicentennial of the Constitution records
, 2017 The Commission on the Bicentennial of the Constitution (the Commission), consisting of 23 members appointed by President Ronald Reagan, was charged with promoting and coordinating activities to commemorate the 200 year anniversary of the Constitution ...
Commission on the Bicentennial of the Constitution
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A comprehensive coin dataset highlighting the numismatic heritage of Bangladesh. [PDF]
Data BriefHasan M, Roy K, Tasnia N, Rashid MRA.
europepmc +1 more source