Results 91 to 100 of about 637,600 (304)

Monastic Traditions and Practices in Macedonia and Their Implications in Modern Times

, 2017
The purpose of this paper is to present several fundamental aspects in the reconstruction of the issue related to the monasticism in Macedonia. In that sense, taken into consideration is the historical and spiritual continuity of the monasticism ...
Angelovska-Panova, Maja
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The origins of the university: Questions of identity and historical continuity

Church, Communication and Culture
In this article I intend to make an inquiry into the essential values of the university in its medieval origins and to compare them with the present situation of the institution, and the main challenges it faces today. In the first part of the article, I
Jaume Aurell
doaj   +1 more source

Incorporating Topography into Landscape Continuity Analysis—Hong Kong Island as a Case Study

Land, 2013
The increase in population and the expansion of built-up areas into natural and agricultural areas results in more than just loss of open spaces surrounding cities.
Matan E. Singer, Noam Levin, Poh Chin Lai   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Discourses of Historical Memory (Continuation)

Discourse-P, 2017
In the continuation of the article subject to review will be the methods and means by which social institutions perform the work on deciphering structures of identity of people from other historical periods, which can be applied for the analysis of our own identity, for the opening of discourse, imaginative nature of our own historical consciousness ...
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

05 Actualization of continuity in labor education of children of preschool and primary school age: Ukrainian context (1890- 1917)

International Journal of Social and Educational Innovation, 2016
Integration of education of Ukraine into the European educational space actualizes the problem of studying educational theory and practice to develop productive ideas that can be adapted to the content and methodical support, training and education of ...
Eugen Antypin
doaj  

Arapot vo makedonskata narodna kniževnost i negovi paraleli na Mediteranot
The Black Arab in Macedonian Folk Literature and Parallels in the Mediterranean Folklore

Studia Mythologica Slavica, 2011
The continuity/duration of the figure of the Arab (in Macedonian folk literature) is not maintained in the same manner and to the same extent in all areas. This implies the problem of substrata and the super-strata.
Lidija Stojanović
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source