Results 81 to 90 of about 637,600 (304)

Sustaining the Fabric of Time: Urban Heritage, Time Rupture, and Sustainable Development

Land
This paper explores the concept of time rupture, i.e., the disruption of historical continuity caused by rapid urbanization, and its implications for urban heritage preservation, using Dongjiadu in Shanghai as a case study.
Kaixuan Wang, Kalliopi Fouseki
doaj   +1 more source

Repatriation and the Radical Redistribution of Art [PDF]

, 2017
Museums are home to millions of artworks and cultural artifacts, some of which have made their way to these institutions through unjust means. Some argue that these objects should be repatriated (i.e.
Matthes, Erich Hatala
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

KESINAMBUNGAN DAN PERUBAHAN: PEMANFAATANNYA SEBAGAI KERANGKA PEMBELAJARAN SEJARAH

Sejarah dan Budaya: Jurnal Sejarah, Budaya, dan Pengajarannya, 2018
Pemikiran historis menjadi perhatian kita sebagai guru sejarah. Pembelajaran sejarah sebenarnya merupakan pembelajaran disiplin ilmu sejarah. Disiplin ilmu sejarah menuntut kita untuk berpikir sejarah.
Susanto Yunus Alfian
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Strategies for the continuity of the historical city: the denied maintenance approach

Agathón, 2017
Widening the concept of temporal continuity – which invokes the unavoidable changeover between fathers and sons – to the field of anthropic transformation, allows reflecting on the historical city and on the current regenerative changes concerning it ...
Massimo Lauria, Maria Azzalin
doaj   +1 more source

On the historical continuity of the process of economic growth [PDF]

, 1997
Pooled regressions first of 8 and then of 16 countries show a steady and robust process of endogenous growth since 1870, interrupted only by the events of World War II and the impact of convergence towards US levels of performance in the 1950s and the 1960s.
Theo van de Klundert, Anton van Schaik
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Duhem: Images of Science, Historical Continuity, and the First Crisis in Physics

Transversal: International Journal for the Historiography of Science, 2017
Duhem used historical arguments to draw philosophical conclusions about the aim and structure of physical theory. He argued against explanatory theories and in favor of theories that provide natural classifications of the phenomena. This paper presents
Michael Liston
doaj   +1 more source