Results 51 to 60 of about 4,499,602 (300)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

The Chinese development state model: historical origins and institutional continuity

open access: yesRussian Journal of Economics and Law
Objective: to prove an institutional link between the historical practices of state regulation of economic life in pre-revolutionary China and the modern architecture of the PRC’s “development state”; to determine the role of the supreme power ...
M. S. Kruglova
doaj   +1 more source

The prefaces of Afsharid Historical Texts; Continuity and Transition in Iranian Historiography [PDF]

open access: yesتاریخ نگری و تاریخ نگاری, 2011
Preface writing is an old and the constant tradition in Iranian historiography that has been continued from 11th century to the present time. Although this part of historiography relatively has constant elements and templates by external structures from ...
Godarz Rashtiani
doaj   +1 more source

Kansas State Historical Society Annual Report, 2016

open access: yes, 2016
Covers Fiscal Year 2016 The Kansas State Historical Society, Inc., doing business as the Kansas Historical Foundation, is an IRS determined 501(c)(3) non-profit and serves as the fund raising, fund management, membership, and retail organization for the ...
Kansas State Historical Society
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structural Decoding of Lijiang’s Historical Cultural Space: Cultural–Ecological Continuity and Land Governance

open access: yesLand
Long-standing studies of historical cultural spaces have primarily focused on the preservation of heritage objects and landscapes, while insufficient attention has been paid to the structural relationships, land-use transformations, and cultural ...
Xinna Wei   +3 more
doaj   +1 more source

Weaker forms of continuity [PDF]

open access: yes, 1972
This paper is concerned with a study of various weaker forms of continuity. The definitions originated in [1], [2], and [4] . In Chapter I, the definitions of several types of continuity are given and examples are given to show that these are actually ...
Keith, Martha Allred   +1 more
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The evaluation of the technological and functional appropriateness, regarding to the intervention in the former military and service urban heritage

open access: yesTechne, 2016
Architectural interventions in historical contexts throughout most of the 20th century were inter-linked by the two extremes of conservation and transformation.
Rossella Maspoli
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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