Results 91 to 100 of about 1,594,782 (294)

Behavioural Genetics in Criminal Cases: Past, Present and Future [PDF]

open access: yes, 2006
Researchers studying human behavioral genetics have made significant scientific progress in enhancing our understanding of the relative contributions of genetics and the environment in observed variations in human behavior. Quickly outpacing the advances
Bernet, William, Farahany, Nita A.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Hidden figures of nursing: The historical contributions of Black nurses and a narrative for those who are unnamed, undocumented and underrepresented. [PDF]

open access: yesJ Adv Nurs, 2021
Baptiste DL   +24 more
europepmc   +1 more source

Probing Questions for a Forward-Looking People

open access: yes, 1987
At the risk of oversimplifying recent Quaker developments in America, we could consider the 1950s a decade of rediscovery and redefinition among Friends.
Anderson, Paul
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Pedagogía de la memoria y de la paz: herramientas para la implementación de la memoria histórica y la oralidad en la enseñanza de la historia escolar

open access: yesCambios y Permanencias, 2018
The following pedagogical proposal consists of the pedagogy of memory and the peace, attached to social constructivism. this is intended from the peace chair, and its thematic focus.
Jean Carlos Flórez Orellano   +1 more
doaj  

Zaira Cintra Vidal: a trajectory of innovation in Brazilian nursing education

open access: yesRevista Brasileira de Enfermagem
Objectives to analyze the contributions of Zaira Cintra Vidal’s academic-professional trajectory to innovation in Brazilian nursing education. Methods a historical, qualitative study. Direct historical sources, such as written and iconographic documents,
Mayki Bruno dos Santos Gonçalves   +5 more
doaj   +2 more sources

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