Results 91 to 100 of about 4,152,887 (287)
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source
Library activities of Dmytro Bahalii and historical destiny of his personal library [PDF]
Rukopisna ta knižkova spadŝina Ukraïni, 2019 The article is devoted to the investigation of the scientific and cultural heritage of the Ukrainian historian, one of the fi rst members of the Ukrainian Academy of Sciences D. I. Bahalii. The scientist is known to have been engaged both in the scientific and public work.
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Advanced Science, EarlyView.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source
, 2023 The reuse of historical penitentiary architecture is an indispensable measure to guarantee its preservation. This leads to answers that are often difficult to reconcile with the principles of conservation. In fact, although it is possible of referring to the exception, it is essential to confront the reasons invoked by European legislation, which often
openaire +1 more source
Alzheimer's Disease Beyond Amyloid: Lessons From Atherosclerosis
Annals of Clinical and Translational Neurology, EarlyView.
Marcello Ciaccio, Luisa Agnello
wiley +1 more source
Advanced Science, EarlyView.In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma +10 more
wiley +1 more source
Aisthema: International Journal, 2014 The article is about the theme of fortune and of destiny in the biblical world. It takes the historical and religious, philological, literary and theological aspects into account. These aspects go through the age of the old and New Testament. Even if the
Gaetano Di Palma
doaj
Advanced Science, EarlyView.Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan +5 more
wiley +1 more source
Advanced Science, EarlyView.Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang +12 more
wiley +1 more source