Results 241 to 250 of about 2,221,083 (311)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Chinese calligraphy as cultural mediation: a cultural-historical activity theory perspective on therapeutic practice for neuropsychiatric symptoms. [PDF]

Front Psychiatry
Chu KY.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Culturally responsive approaches to brain health and dementia education for American Indian, Alaska Native, and Native Hawaiian communities. [PDF]

Gerontologist
Dorame B, Donnellan K, Babbel B, Eppes R, Benson B, Kuehn K, Dicken M, Hoskins C.   +7 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Application of Causal Inference to Establish Assay Effect in the Absence of a Bridging Study: A Case Study of MenACWY-CRM Conjugate Vaccine Data. [PDF]

Pharm Stat
Adani M, Noirjean S, Callegaro A, Keshavan P, Costantini M.   +4 more
europepmc   +1 more source

From model psychosis to rapid antidepressant: a historical and conceptual review of ketamine's psychiatric history. [PDF]

Ther Adv Psychopharmacol
Cabrera Abreu C, Biorac A, Baldessarini RJ, Vázquez GH.   +3 more
europepmc   +1 more source

Unending dialectical politics of identity in Ethiopia. [PDF]

F1000Res
Assefa T.
europepmc   +1 more source

The Legacy of Chattel Slavery and Its Association with Prostate Cancer Incidences in the Southeastern United States. [PDF]

Cancer Epidemiol Biomarkers Prev
Bharadwaj MC, Holt SK, Iyer HS, Lee JR, Wolff EM, Rebbeck TR, Gore JL, Nyame YA.   +7 more
europepmc   +1 more source