Results 31 to 40 of about 191,185 (286)

Earliest Holocene south Greenland ice sheet retreat within its late Holocene extent [PDF]

, 2014
Early Holocene summer warmth drove dramatic Greenland ice sheet (GIS) retreat. Subsequent insolation-driven cooling caused GIS margin readvance to late Holocene maxima, from which ice margins are now retreating.
Anslow, FS, Axford, Y, Brook, EJ, Carlson, AE, Legrande, AN, Rood, DH, Sinclair, G, Ullman, DJ, Winsor, K   +8 more
core   +1 more source

Maritime post routes between Corunna and the Caribbean as a Geographic Information System (Gis) model

Culture & History Digital Journal, 2015
In 1764, the Secretariat of State created the Maritime Post in order to establish regular, reliable communications with the colonies in the Americas. This was the first in a series of decisive measures which advanced the spread of free trade.
María Baudot Monroy
doaj   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

La Carta idrografica d’Italia come fonte per la storia degli opifici idraulici alla fine dell’Ottocento. Il caso toscano

Bollettino della Società Geografica Italiana, 2021
In all pre-industrial societies, water power has been the main form of energy used to drive grain and oil mills, ironworks, fulling mills, paper factories and other types of craft and manufacturing activities.
Camillo Berti, Massimiliano Grava
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Paikkatietoa ja muistitietoa yhdistämässä. Porin Pihlavan muistin paikkoja

J@rgonia, 2023
Yhdistämällä muisti- ja paikkatietoa voidaan tunnistaa ja vahvistaa tutkimuskohteena olevan alueen asukkaiden ja muiden sidosryhmien yhteisöllisiä merkityksenantoja. Tarkastelen Porin Pihlavan muistin paikkoja ja niihin kiinnittyviä muistoja, kokemuksia,
Virtanen, Katrina
doaj  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Using Geographic Information Science to Map the Flight of the Regicides in Seventeenth- century New England [PDF]

, 2016
In mid-seventeenth century two of the judges who condemned King Charles I of England to death became regicide fugitives when his son came to the throne as Charles II. The two men fled to New England and eluded their Royalist pursuers for twenty years.
Cowley, Steven
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source