Results 41 to 50 of about 12,315 (258)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Cartographic visualization of Jewish heritage in cross-border tourist project Shtetl Routes (Poland, Belarus, Ukraine)

Polish Cartographical Review, 2016
The aim of the author of this article is to present cartographic visualizations designed for an international tourist project Shtetl Routes. The methodology consists of the study of early topographic maps, field studies, GIS analyses and 3D modelling. 63
Kuna Jakub
doaj   +1 more source

Historical geocoding assistant

SoftwareX, 2021
The growing use of geographic information systems (GIS) and geographical analyses in different areas of the digital humanities highlights the need for geocoding, i.e. assigning geographic coordinates to records in a dataset.
Adam Mertel, David Zbíral, Zdeněk Stachoň, Hana Hořínková   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Power Interactions in the Evolution of Urban Road Networks: A Case Study of Nanjing since the Ming Dynasty

Redai dili
Power perspective is important for understanding how urban road networks operate, promote public participation, and improve operational efficiency. Taking Nanjing (1368—1978) as an example, a six-century historical geographic information dataset of the ...
Bai Xuefeng, Wang Shuo, Jiang Wencheng, Sakai Takeru, Xu Hao   +4 more
doaj   +1 more source

The Transport Revolution on Land and Sea: Farming, Fishing, and Railways in Great Britain, 1840-1914

HoST, 2018
The introduction and expansion of rapid rail transportation in Great Britain helped transform sea fishing and make fresh fish a new commodity of mass consumption.
Schwartz Robert M.
doaj   +1 more source

Machine-Learning-Enhanced Procedural Modeling for 4D Historical Cities Reconstruction

Remote Sensing, 2023
The generation of 3D models depicting cities in the past holds great potential for documentation and educational purposes. However, it is often hindered by incomplete historical data and the specialized expertise required. To address these challenges, we
Beatrice Vaienti, Rémi Petitpierre, Isabella di Lenardo, Frédéric Kaplan   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source