Results 31 to 40 of about 12,315 (258)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Benchmarking large language models for geolocating colonial Virginia land grants
Journal of Spatial Information ScienceVirginia's seventeenth- and eighteenth-century land patents survive primarily as narrative metes-and-bounds descriptions, limiting spatial analysis. This study systematically evaluates current-generation large language models (LLMs) in converting these ...
Ryan Mioduski
doaj +1 more source
Creating a common symbol classification for a new historical geoportal of Poland
Miscellanea Geographica: Regional Studies on Development, 2014 The crowd-sourcing approach should be implemented into a new historical geoportal of Poland due to its increasing potential in WebGIS. Registered users will be able to acquire spatial data from various map series.
Panecki Tomasz
doaj +1 more source
Bridging the Past and Present: A GIS-Based System for Managing Ankara’s Multi-Layered Urban Heritage [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesCities that have been continuously inhabited and embody the spatial traces of historical continuity are defined as “multi-layered”. The remnants of historical periods and cultures, which constitute the stratified layers of the city and the ...
Z. B. Üstün, A. G. Bilgin Altınöz
doaj +1 more source
Quantitative Research on Historic City Landscape Value Assessment Based on AHP-GIS
Taiyuan Ligong Daxue xuebao, 2021 The historic urban landscape (HUL) concept is a protection concept proposed for the “continuous” change characteristics and “layered” presentation of cultural landscapes in cities in time series.
Zexin LEI, Junjie LUO, Lei CAO
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
GIS METHODS AND ANALYSIS OF ARCHAEOLOGICAL LAYERS IN THE TOPLICA DISTRICT (SERBIA)
Zbornik Radova: Geografski institut "Jovan Cvijić", 2019 In this paper, we are explaining a decade long investigation of historical, sacral and archaeological sites in the Toplica District (Serbia) as one of the significant cultural heritage sites in Europe with more than 226 objects with different time of ...
Aleksandar Valjarević +4 more
doaj +3 more sources
Polish Cartographical Review, 2019 The aim of the author is to present the methodology of reconstruction of the Old-Polish transport network as exemplified by the historic Lublin Voivodship.
Zawadzki Mateusz
doaj +1 more source