Results 121 to 130 of about 4,978,738 (338)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Hydrological summary for the United Kingdom: March 2002 [PDF]

, 2000
The monthly summary of hydrological conditions in the United Kingdom is compiled as part of the National Hydrological Monitoring Programme (a joint CEH and BGS enterprise).
Marsh, Terry, Sanderson, Felicity
core   +6 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Automatic Vectorization of Historical Maps

GEOmedia
For the most diverse practical purposes and communication needs (from trade to conquests or exploratory voyages), man has always represented space through the production of maps.
Elisa Farella, Salim Malek, Fabio Remondino   +2 more
doaj  

Translating sociocultural transformations into historical maps on land use changes: the case of Lafkenmapu (Araucanía, Chile)

, 2020
While it is widely known that socio-cultural transformations have a spatial impact on geographical areas, limited attention has been paid to mapping such transformations. This paper aims to explore how historical maps of land-use changes can be excellent
F. Peña-Cortés, Miguel Escalona, J. A. Soria-lara, J. Pincheira-Ulbrich, Camila Salinas-Silva, Freddy Alarcón   +5 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Beach Erosion in the Gulf of Castellammare di Stabia in Response to the Trapping of Longshore Drifting Sediments of the Gulf of Napoli (Southern Italy)

Geosciences, 2018
The results of this study have allowed verification that longshore sediment transport along the coast of Napoli Gulf (southern Italy) takes place from Northwest to Southeast.
Micla Pennetta
doaj   +1 more source

History of Soil Geography in the Context of Scale [PDF]

, 2015
We review historical soil maps from a geographical perspective, in contrast to the more traditional temporal–historical perspective. Our geographical approach examines and compares soil maps based on their scale and classification system.
Miller, Bradley, Miller, Bradley, Schaetzl, R. J.   +2 more
core   +2 more sources

Kartta Labs: Unrendering Historical Maps

GeoAI@SIGSPATIAL, 2019
This paper introduces the Kartta Labs project, an ongoing open-source and open-data project aiming at organizing the world's historical maps and making them universally accessible and useful.
Sasan Tavakkol, Yao-Yi Chiang, T. Waters, Feng Han, Kisalaya Prasad, Raimondas Kiveris   +5 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source