Results 91 to 100 of about 202,912,194 (286)

Endangered Commons? Modeling the Effects of Demographic Trends Coupled with Admission Rules to Common Property Institutions

Land
This study investigates the long-term effects of demographic trends and admission rules on common properties in the Province of Trento, Italy, which we refer to as historical commons. Historical commons have evolved into socio-ecological systems over the
Cristina Dalla Torre, Rocco Scolozzi, Elisa Ravazzoli, Paola Gatto   +3 more
doaj   +1 more source

A machine learning method for estimating atmospheric trace gas concentration baselines [PDF]

Atmospheric Measurement Techniques
Estimates of trace gas baseline mole fractions in high-frequency atmospheric measurement records are crucial for analysing long-term changes in atmospheric composition.
K. Gerrand, K. Gerrand, E. Fillola, E. Fillola, A. J. Manning, A. J. Manning, J. Arduini, P. B. Krummel, C. R. Lunder, J. Mühle, S. O'Doherty, S. Park, R. G. Prinn, S. Reimann, D. Young, M. Rigby   +15 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Algorithms and Models Implemented in ESTE Tool for Rapid Radiological Consequences Assessment After Nuclear Explosion

Atmosphere
This paper describes a new methodology implemented in the ESTE decision support system for evaluating the source term resulting from a nuclear weapon detonation.
Michal Marčišovský, Ľudovít Lipták, Mária Marčišovská, Miroslav Chylý, Eva Fojcíková, Monika Krpelanová, Peter Čarný   +6 more
doaj   +1 more source

Changes in Snowbed Vegetation in the Western Carpathians Under Changing Climatic Conditions and Land Use in the Last Decades

Ekológia (Bratislava), 2019
Snowbed vegetation is one of the most sensitive alpine vegetation type to the climate change, because shortened period of snow cover has essential impact on the snowbed environment.
Palaj Andrej, Kollár Jozef
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of isolation and environmental variables on fish community structure in the Brazilian Amazon Madeira-Purus interfluve

Brazilian Journal of Biology
Due to the existence of terrestrial barriers to freshwater fish dispersion, it is believed that its distribution is strongly associated with historical factors related to the formation of the habitats they occupy.
DF. Barros, ALM. Albernaz, J. Zuanon, HMV. Espírito Santo, FP. Mendonça, AV. Galuch   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The peculiarities of the daily life of the Russian and German military elites in the late 19th and early 20th centuries: a comparative analysis

Вестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The interest in the research topic is due to the need to study the adaptation of the military elites of Russia and Germany to the challenges of modernization at the turn of the 19th–20th centuries through the prism of their daily practices ...
G. S. Chuvardin
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source