Results 81 to 90 of about 202,912,194 (286)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
JAC: A Journal of Composition Theory
, 2000 JAC: A Journal of Composition Theory contains a collection of papers regarding writing and rhetoric: "The JAC is a forum for theory, research and pedagogy regarding (1) those writing courses beyond the freshman courses, excluding technical and creative ...
Worsham, Lynn +1 more
core
Generalbass Schule. Thoroughbass School Edited and Translated by Derek Remeš [PDF]
Zeitschrift der Gesellschaft für Musiktheorie, 2019 Johann Christian Kittel, Derek Remeš
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
JAC: A Journal of Composition Theory
, 1995 JAC: A Journal of Composition Theory contains a collection of papers regarding writing and rhetoric: "The JAC is a forum for theory, research and pedagogy regarding (1) those writing courses beyond the freshman courses, excluding technical and creative ...
Association of Teachers of Advanced Composition (U.S.) +1 more
core
Florian Vogt, Die »Anleitung zur musikalischen Setzkunst« von Gottfried Heinrich Stölzel (1690–1749). Edition und Kommentar, Neumünster: von Bockel 2018 [PDF]
Zeitschrift der Gesellschaft für Musiktheorie, 2019 Almut Gatz
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Studying historical occupational careers with multilevel growth models [PDF]
In this article we propose to study occupational careers with historical data by using multilevel growth models. Historical career data are often characterized by a lack of information on the timing of occupational changes and by different numbers of ...
Ineke Maas, Wiebke Schulz
core
Scientific ReportsEfficient processing of complex ores is often hampered by an incomplete understanding of the spatial distribution of critical mineralogical properties. Here, we introduce a machine learning-based framework that addresses this gap.
A. O. Kalashnikov +3 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source