Results 41 to 50 of about 107,224 (302)
Dermatologic Clinics, 1991 AIDS has been a recognized clinical entity now for just 10 years. In that time in the United States alone, it is estimated that 1 to 2 million people may be infected with HIV. Estimates of numbers infected worldwide are as high as 10 million. Over these 10 years, considerable progress has been made.
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A NUTRITION OVERVIEW THROUGH CENTURIES. THE PRESENT-DAY NEED OF NUTRITIONAL EDUCATION IN SCHOOLS [PDF]
Challenges of the Knowledge Society, 2015 The type of alimentation and the food quality of individuals has undergone remarkable changes along with the progress of the human species. This study contains an historical overview regarding human nutrition from the primitive forms until the paradoxes ...
Simona ILAŞ
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Ecology and Society, 2017 Today's global challenges (e.g., food security) are not unprecedented in human history. Starting with the Neolithic transition, the agricultural sector and society underwent several cultural and technological changes and endured natural challenges. These
Sandra Teuber +5 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Knjižnica, 2006 The article describes further efforts to implement library automation in the Slovene National and University Library and other libraries in the period from 1977 to 1979.
Stanislav Bahor
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Historical Overview of Space Medicine
McGill Journal of Medicine, 2020 N ...
David R. Williams
doaj +1 more source