Results 41 to 50 of about 1,264,024 (294)

Politics as usual? The Trials and Tribulations of the Law of Historical Memory in Spain [PDF]

, 2008
The aim of this article is to evaluate the Law of Historical Memory from a political perspective where politics is understood as "the art of the possible".
Blakeley, Georgina
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Real Debate over the Senate’s Role in the Confirmation Process [PDF]

, 2000
The five Supreme Court nominations between 2005 and 2010 brought renewed attention to the Senate’s role in the confirmation process. This Note explores the debate over the Senate’s proper role in that process.
Lambert, William Grayson
core   +2 more sources

Gendering Memory: Intersectional Aspects of the Polish Politics of Memory

Przeglad Socjologii Jakosciowej, 2020
The article is devoted to the process of gendering memory as a counterpoint to the politicization of memory observed in the Polish context. The core problem of the paper is a description of a local case of this type of gender ‘memory practising’ in the ...
Inga Kuźma, Edyta Pietrzak
doaj   +1 more source

Historical politics of the Polish People’s Republic in the Russian historiography of the XXI century

Гуманитарные и юридические исследования, 2023
Introduction. The article is devoted to the development of the Russian historiography of the study of the historical politics of the Polish People’s Republic.
M. A. Martynenko
doaj   +1 more source

Historicizing the Emergence of Global Mental Health in Nepal (1950-2019) [PDF]

, 2020
This article traces a genealogy of mental health governance in Nepal as it was constituted in and through an assemblage of historical events, local politics, personal relationships and trends in the field of global health development.
Seale-Feldman, Aidan
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Not by Timur alone: ignoring the Shibanids within the framework of the “Centralized State” concept

Золотоордынское обозрение
Research objectives: To investigate the historical reasons for the neglect of the Shibanid dynasty in the historical scholarship and political discourse of Uzbekistan within the framework of the “Centralized State” concept.
Alimdjanov B.A., Zamonov A.T.
doaj   +1 more source

Integration Policy in Northwestern Region of Russian Empire in Second Half of 19th — Early 20th Centuries

Научный диалог, 2023
The article examines the commemorative practices implemented by the Russian authorities in the Northwestern region at the end of the 19th and beginning of the 20th centuries, which were a key element of the integrative strategy of ‘soft power’.
M. N. Krot, O. O. Zavyalova
doaj   +1 more source