Results 51 to 60 of about 1,273,492 (312)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Not by Timur alone: ignoring the Shibanids within the framework of the “Centralized State” concept

Золотоордынское обозрение
Research objectives: To investigate the historical reasons for the neglect of the Shibanid dynasty in the historical scholarship and political discourse of Uzbekistan within the framework of the “Centralized State” concept.
Alimdjanov B.A., Zamonov A.T.
doaj   +1 more source

Integration Policy in Northwestern Region of Russian Empire in Second Half of 19th — Early 20th Centuries

Научный диалог, 2023
The article examines the commemorative practices implemented by the Russian authorities in the Northwestern region at the end of the 19th and beginning of the 20th centuries, which were a key element of the integrative strategy of ‘soft power’.
M. N. Krot, O. O. Zavyalova
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Od internacjonalnej do własnej historii – mniejszość białoruska w Polsce

Acta Baltico-Slavica, 2017
From international history to one’s own history – Belorusian minority in Poland After World War II the Belarusians who did not leave Poland could gain upward mobility only if they avoided displaying their national and cultural distinctiveness ...
Wojciech Śleszyński
doaj   +1 more source

The political economy of global environmental governance [PDF]

, 2008
This article develops a political economy account of global environmental governance to improve upon our understanding of the contemporary conduct of environmental politics and to clarify thinking about the potential for, and barriers to, effective ...
Newell, Peter
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Water and Power in Manchuria in the Late 19th - First Third of the 20th Centuries: Geopolitical Rivalry and the Struggle of Narratives in Russian-Language and English-L anguage Scholarly Works

RUDN Journal of Political Science
Drawing on the sustained scholarly interest in the “struggle for Manchuria” and the pressing need for critical source analysis, particularly in the context of the contemporary geopolitical landscape of the Asia-Pacific region, this article revisits the ...
Pavel N. Dudin
doaj   +1 more source

Book review: history, heritage and tradition in contemporary British politics [PDF]

, 2012
This book explores the use of the past in modern British politics. It examines party political perspectives on British history and the historical process, and also looks at the ways in which memory is instituted within the parties in practice, through ...
Cowman, Krista
core