Results 41 to 50 of about 25,901 (264)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Water and Power in Manchuria in the Late 19th - First Third of the 20th Centuries: Geopolitical Rivalry and the Struggle of Narratives in Russian-Language and English-L anguage Scholarly Works

RUDN Journal of Political Science
Drawing on the sustained scholarly interest in the “struggle for Manchuria” and the pressing need for critical source analysis, particularly in the context of the contemporary geopolitical landscape of the Asia-Pacific region, this article revisits the ...
Pavel N. Dudin
doaj   +1 more source

Wojna polsko-polska na terenie Izraela

Studia Litteraria et Historica, 2012
The Polish – Polish war on the territory of Israel The text deconstructs a documentary film Betar by Robert Kaczmarek and Piotr Gontarczyk. The author carries out the analysis adopting two approaches. Firstly, she confronts the factographic side of the
Anna Zawadzka
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The Commandant's genius era – historical argument as an element constituting the political identity of the Piłsudski camp.

Humanities and Social Sciences, 2018
“The era in which the Commandant's genius flourished did not come to an end along with his death. We are still living in the same epoch”[1] said the prime minister Sławoj Składkowski in the speech which he delivered in the Polish parliament on taking the
Arkadiusz ADAMCZYK
doaj   +1 more source

Historical policy as a tool for changing the ethnocultural situation in Silesia

Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Ìсторія України. Українознавство: історичні та філософські науки, 2023
This article examines the impact of historical policy on the ethnocultural situation in the Silesian region.  The article analyzes various aspects of political decisions that influence the formation and transformation of ethnic and cultural identities in
Vsevolod Serhiienko
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Non-classical mnemonic actors and new commemorative practices in the network space

Вестник университета
The research focuses on non-classical mnemonic actors – video bloggers and creators of computer games. As part of the study of new commemorative practices, we consider video blogs focused on historical topics, internet memes of historical orientation ...
I. S. Soldatenko
doaj   +1 more source

Building the past, forgetting the future: Is Poland a historical knowledge based society?

Creativity Studies, 2008
The article attempts to analyze the public debate in a present day Poland focused on the country's recent history and memory (or memories). The author believes that among other lines dividing Polish society, the cultural line separating opposing ...
Radoslaw Poczykowski
doaj   +1 more source