Results 81 to 90 of about 1,646,641 (334)

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Earthquakes in India and the Himalaya: tectonics, geodesy and history

Annals of Geophysics, 2004
The record of earthquakes in India is patchy prior to 1800 and its improvement is much impeded by its dispersal in a dozen local languages, and several colonial archives. Although geological studies will necessarily complement the historical record, only
R. Bilham
doaj   +1 more source

A Revised Historical Light Curve of Eta Carinae and the Timing of Close Periastron Encounters

, 2010
The historical light curve of the 19th century "Great Eruption" of etaCar provides a striking record of violent instabilies encountered by the most massive stars.
Abbott, Bennett, Bond, Corcoran, Crowe, Currie, Damineli, Damineli, Damineli, David J. Frew, Davidson, Davidson, de Vaucouleurs, Drake, Evans, Feast, Frew, Gallagher, Gaviola, Gehrz, Gilliss, Gilliss, Gomez, Hamacher, Herschel, Hillier, Hoskin, Humphreys, Humphreys, Innes, Innes, Ishibashi, Jacob, Jacob, Kashi, Kulczycky, Leps, Li, Mackay, Maclear, Maclear, Maclear, Maclear, Mehner, Mermilliod, Moesta, Morse, Morse, Müller, Nathan Smith, Okazaki, Parkin, Pastorello, Pittard, Polcaro, Ringuelet, Royal Astronomical Society, Schaefer, Schaefer, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smith, Smyth, Smyth, Smyth, Spreckley, Stanbridge, Stanbridge, Tammann, Tebbutt, Van Dyk, Wagner, Walborn, Walborn, Warner, Whitelock   +86 more
core   +1 more source

Using experimental manipulation of questionnaire design and a Kenyan panel to test for the reliability of reported perceptions of climate change and adaptation [PDF]

, 2020
While the use of surveys to understand perception of climate change and adaptation is common in research on agriculture, the reliability of aspects of the methodology is still largely untested. In particular there is limited evidence on (i) the degree to
MUNRO Alistair, 政策研究大学院大学 / National Graduate Institute for Policy Studies   +1 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Commercial bank load loss recoveries [PDF]

, 2009
We present a new approach to analyse historical recovery rates on distressed bank assets. Our approach uses banks’ reported impaired assets and the corresponding specific provisions. The dynamics and drivers of this credit loss recovery proxy are studied
Grimes, Arthur, Hess, Kurt
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Combining instrumental, historical, and coastal marine sedimentary archives to analyse floods variability in northwestern Italy during the last thousand years

Quaternary Science Advances
Understanding Earth's changing climate is a crucial challenge. However, the available time series of direct measurements are often insufficient to fully capture climatic processes that unfold over centuries and millennia.
Giovanni Coletti, Laura Borromeo, Luca Fallati, Marco Luppichini, Agostino Meroni, Francesco Maspero, Elisa Malinverno, Monica Bini, Jordan Palli, Daniela Basso, Giovanni Vezzoli, Eduardo Garzanti, Valentina Alice Bracchi, Alessandra Savini, Fabien Desbiolles, Claudia Pasquero, Annamaria Correggiari, Irene Cornacchia, Chiara Boschi, Ilaria Baneschi, Alessandro Cavallo, Matteo Masotta, Giulia Bosio, Andrea Gallerani, Nicoletta Fusi, Luca Mariani, Anna Galli, Sergio Andò, Pietro Bazzicalupo, Sirio Consani, Marco Lazzarotti, Gregorio Taccola   +31 more
doaj   +1 more source