Results 191 to 200 of about 1,898,566 (310)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Analyzing the distribution patterns of soybeans and rapeseeds in china under future climate change scenarios utilizing the maxent model. [PDF]

PLoS One
Xiang Y, Han Z, Zhang S, Wei F.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pan-Continental Genomic Analysis of Eurasian Perch Uncovers Global Diversity Hotspots and Postglacial Recolonization Patterns. [PDF]

Ecol Evol
Lichman V, Ozerov M, López ME, Noreikiene K, Kahar S, Pukk L, Burimski O, Japoshvili B, Blazhekovikj-Dimovska D, Lajus D, Nikolić D, Ribeiro F, Gebauer T, Kouřil J, Peterka J, Blabolil P, Čech M, Jůza T, Kubečka J, Muška M, Šmejkal M, Vašek M, Kahilainen K, Ložys L, Carlsson J, Corcoran W, Yilmaz Ö, Eklöv P, Takács P, Bánó B, Pallos R, Kazakov S, Pehlivanov L, Lecocq T, Lambert S, Lauridsen T, Berthelsen A, Raposeiro P, Verreycken H, Britton R, Borcheling J, Kutsokon Y, Didenko O, Jurajda P, Miranda R, Gross R, Vasemägi A.   +46 more
europepmc   +1 more source

Henri Pirenne (1862-1935): a Belgian historian and the development of social and historical sciences: introduction [PDF]

, 2011
Keymeulen, Sarah
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Redefining social medicine from Latin America: Historical foundations and contemporary directions. [PDF]

PLOS Glob Public Health
Ortega F, Abarca-Brown G.
europepmc   +1 more source

Historical understanding of science

, 2015
En este breve ensayo, el autor va explicando con algún detalle la formación de la ciencia a partir de la comprensión que la epistemología hace de ella. Recorre, sin embargo, solo cuatro momentos claves: su formación, la revolución moderna, el cientificismo del siglo XIX y finalmente, la comprensión realizada por la epistemología ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Editorial: Exploring health disparities in black communities: historical perspectives, present challenges, and future directions. [PDF]

Front Public Health
Bonnechère B, Ijadunola K, Yesuf EA, Blanc J, Sethi Y.   +4 more
europepmc   +1 more source