Results 61 to 70 of about 353,625 (313)
Philosophy Kitchen, 2019 In his book, History as a Science and the System of the Sciences, Thomas Seebohm articulates the view that history can serve to mediate between the sciences of explanation and the sciences of interpretation, that is, between the natural sciences and the ...
Marina Paola Banchetti-Robino
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Sciences historiques et classification des sciences
Cahiers François Viète, 2005 What is a historical science? The study of the classifications of sciences, not devoid of interest in itself, undoubtedly makes it possible to answer this question with precision.
Patrice Bailhache
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Historical Studies in the Physical Sciences, vol. 2, 1 970 [PDF]
, 1975 Cazenave M.-L. Historical Studies in the Physical Sciences, vol. 2, 1 970. In: Revue d'histoire des sciences, tome 28, n°3, 1975.
Cazenave, M.-L.
core
Journal of Islam and Social Sciences; No. 23 [PDF]
The journal is set to publish original articles on a wide range of issues including; Social philosophy: (in the Quran and other religious texts and the tradition, in the thought of Muslim scholars and comparison of different attitudes and approaches);
Islam and Social Sciences, J (via Mendeley Data)
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Islam and Social Sciences; No. 28 [PDF]
The journal is set to publish original articles on a wide range of issues including; Social philosophy: (in the Quran and other religious texts and the tradition, in the thought of Muslim scholars and comparison of different attitudes and approaches);
Islam and Social Sciences, J (via Mendeley Data)
core +1 more source
Interacting with the Past: Historical Sciences and Historical Games
Teorie vědyHistorical video games are uniquely tied to the scientific practices of professional historians, archaeologists, and many other experts. However, since video games are an interactive medium and the most common-sensical view of history is that the past ...
David Černín
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source