Results 101 to 110 of about 2,470,978 (359)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

"And I was a stockman myself…" Interpreting Aboriginal Women’s Work [PDF]

open access: yes, 1979
Social historians concerned with race relations studies are confronted by enormous gaps in evidence when their research relates to non-literate peoples.
McGrath, Ann
core  

Jet triggered Type Ia supernovae in radio-galaxies?

open access: yes, 2002
We report the serendipitous discovery of a supernova (SN) in the nearby radio-galaxy 3C 78. Observations obtained with the STIS spectrograph on board the Hubble Space Telescope show, at a distance of 0.54 arcsec (300 pc) from the galaxy nucleus, a second
Alessandro Capetti   +5 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

PROFITABILITY OF ALFALFA HAY STORAGE USING PROBABILITIES: AN EXTENSION APPROACH [PDF]

open access: yes
Film managers are usually faced with making decisions involving risk and uncertainty. A common source of risk and uncertainty is related to price variability.
Myer, Gordon L., Shane, Ronald L.
core   +1 more source

Open Source Dataset and Machine Learning Techniques for Automatic Recognition of Historical Graffiti

open access: yes, 2018
Machine learning techniques are presented for automatic recognition of the historical letters (XI-XVIII centuries) carved on the stoned walls of St.Sophia cathedral in Kyiv (Ukraine).
J Ancelet   +7 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Russian Diaries and Memoirs about War for Polish Succession (1733-1735) as Historical Sources

open access: yesНаучный диалог, 2018
The article is devoted to the use of diaries and memoirs as historical sources in the study of the war for the Polish Succession of 1733-1735. Relevance of present research is explained by low degree of studying of the given military conflict in the ...
O. V. Saprikina, K. M. Belyukov
doaj   +1 more source

Land use change detection with LANDSAT-2 data for monitoring and predicting regional water quality degradation [PDF]

open access: yes
The author has identified the following significant results. Comparison between LANDSAT 1 and 2 imagery of Arkansas provided evidence of significant land use changes during the 1972-75 time period.
Dillard, T.   +6 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

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