Results 111 to 120 of about 244,749 (267)

Historical Contingency Drives Freshwater Microbial Community Assembly Across Successional Time. [PDF]

Ecol Evol
Zhang F, Zhang X, Yan D, Jing Y, Wang Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Two hundred years of historical spawning and nursery data for coregonine fishes in the Laurentian Great Lakes. [PDF]

Sci Data
Brant CO, Silvis S, Bennion DH, Castiglione C, Tyrrell K, Hannahs K, Slattery M, Bunnell D, Honsey A, Tingley R, King K, Alofs KM, Ackiss A, Bronte CR, Smith J, Herbert M.   +15 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Structured knowledge representation of the South China Sea: An LLM-based knowledge graph approach. [PDF]

PLoS One
Zhao R, Han Z, Liu H.
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Bayesian sample size determination using robust commensurate priors with interpretable discrepancy weights. [PDF]

Stat Methods Med Res
Whitehead LE, Wason JM, Sailer O, Zheng H.   +3 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Unlocking the Past to Protect the Future: Forensic DNA and Historical Specimens Reveal the Origins of Smuggled Yellow-Headed Parrots. [PDF]

Evol Appl
Ramirez BR, DeRaad DA, Muhlheim AE, Latas P, Durham B, Buxton N, Mutchler MJ, Kirsch EJ, Tsai WLE, Pizarro AK, McCormack JE.   +10 more
europepmc   +1 more source

The Qurʾān as a Historical Source

Journal of the International Qur’anic Studies Association
Abstract The redirection of the qiblah to the Kaʿbah (Q 2:142-5) is redated from 622, very soon after the hijrah where it is placed in the sīrah, to 628 on the eve of the Prophet’s negotiations with the leaders of Mecca at al-Ḥudaybiyah.
openaire   +1 more source