Results 111 to 120 of about 2,484,825 (307)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

A Critical Review of “The Ghaznavid and Seljuq Turks: Poetry as a Source for Iranian History” [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
The aim of this article is to critically review “The Ghaznavid and Seljuq Turks: Poetry as a Source for Iranian History”. Using Farrokhi and Mo῾zziʼs poem as the historical source for Ghaznavid and Seljuq period is the fundamental aim of this book and ...
Yazdan Farrokhi
doaj  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Source control SUDS delivery on a global scale and in Scotland including approach by responsible organisations and professional groups [PDF]

open access: yes, 2013
Background to researchThe Sustainable Urban Drainage Scottish Working Party via CREW commissioned this work on the implementation of source control for SUDS in Scotland.
Berwick, Neil   +4 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The plot thickens

open access: yes, 2011
Fiction based on real people and events poses particular challenges for the writer. While the outline of the story has already been sketched by reality, sometimes the plethora of facts can be overwhelming, making it difficult for the writer to find the ...
Richardson, Heather
core  

A survey of the material and intellectual consequences of trading in undocumented ancient coins : a case study on the North American trade [PDF]

open access: yes, 2008
Ancient coins are among the most widely collected and demanded objects among American collectors of antiquities. A vocal lobby of ancient coin dealers/collectors has arisen to protect the importation of undocumented material into the United States and ...
Elkins, Nathan T.
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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