Results 41 to 50 of about 244,749 (267)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

On S.F. Platonov's review of V.G. Druzhinin's book

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2022
This article considers, with the involvement of archival materials introduced into scientific use for the first time, an unknown fact with S.F. Platonov’s unfinished review of the book by V.G. Druzhinin, which originated from his master’s thesis.
V.V. Mitrofanov
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

History and Truth: the interaction possibilities of theological and historical methodologies [PDF]

open access: yesВестник Православного Свято-Тихоновского гуманитарного университета: Серия ИИ. История, история Русской Православной Церкви, 2014
In the given text the author attempts to offer a statement of the question about relations between theological and historical methodologies. Universal categories - History and Truth - work as a general scheme of discourse.
Mikhailov Petr
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

THE ROLE OF JOURNALISM AS A HISTORICAL SOURCE IN STUDYING THE PROBLEMS OF CONTEMPORARY RUSSIAN HISTORY

open access: yesВестник Кемеровского государственного университета, 2014
The paper provides an assessment of journalism as a historical source for studying the problems of contemporary Russian History. The development stages and genres of journalism are defined and characterized.
K. A. Zabolotskaya
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Из тридцати фарфоровых осколков: история атрибуции вазы из коллекции Омского музея изобразительных искусств имени М.А. Врубеля

open access: yesИскусство Евразии
Статья посвящена истории атрибуции вазы из фонда художественной керамики и стекла Омского областного музея изобразительных искусств имени М.А. Врубеля. Актуальность исследования определена необходимостью атрибуции, систематизации, каталогизации музейных ...
Ермола, М.В.
doaj   +1 more source

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