Results 81 to 90 of about 202,374 (316)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Enlivening the dying ruins: history and archaeology of the Jesuit Missions in Ethiopia, 1557–1632
Culture & History Digital Journal, 2013 A summary is presented of the recent archaeological research led by the University Complutense of Madrid on the residences and monuments of the Jesuit missions in Ethiopia, most of them built at the end of the Mission period, between 1621 and 1632.
Víctor M. Fernández
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A Century of Migration (1830–1939): 735,000 Enriched Records from Bremen’s Ship Passenger Lists
DataThis paper publishes 735,000 historical passenger entries from the German North Sea port of Bremen, created between 1830 and 1939, and now structured, enriched, and processed into a research-ready database.
Tobias Perschl +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Materials and Techniques for the Coating of Nineteenth-century Plaster Casts: A Review of Historical Sources [PDF]
, 2021 Valentina Risdonne +3 more
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The use of historical sources in a multi-layered methodology for karez research in Turpan, China. [PDF]
Water Hist, 2020 Barbaix S +4 more
europepmc +1 more source