Results 81 to 90 of about 334,606 (308)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Cuadernos de Investigación Geográfica, 2018 Historical documents have shown their potential to infer the origin and evolution of the glacier existing in the Veleta cirque, in the massif of Sierra Nevada (Spain).
A. Gómez-Ortiz +4 more
doaj +1 more source
Use of Radioisotope Ratios of Lead for the Identification of Historical Sources of Soil Lead Contamination in Santa Ana, California. [PDF]
Toxics, 2022 Masri S +7 more
europepmc +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Historical Sources [7th grade]
, 2006 This unit introduces the concepts and skills associated with historical research and interpretation. Students will learn how to identify primary and secondary sources and how to interpret sources in a variety of formats.
McPhail, Beth
core
Wrocławski Rocznik Historii Mówionej, 2019 This article addresses the issue of the use of oral accounts in research on very recent history. In particular, the topic of interest is the question of whether oral history in its current form (i.e., given its theoretical, practical, and institutional ...
Marcin Marek Stasiak
doaj +1 more source
When Does the Human Embryonic Heart Start Beating? A Review of Contemporary and Historical Sources of Knowledge about the Onset of Blood Circulation in Man. [PDF]
J Cardiovasc Dev Dis, 2022 Männer J.
europepmc +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Image of Humayun in Historical Sources
, 2021 Zahiriddin Muhammad Babur's historical-memoir "Boburnoma" is widely studied in Uzbek literature. However, the historical work "Humoyunnoma", created by Bobur's daughter Gulbadanbegim as a figurative continuation of "Boburnoma" dedicated to her brother ...
Kizi, Sayfieva Mahliyo Fakhriddin
core +1 more source