Results 201 to 210 of about 87,097 (305)

Discriminative Cut-Offs, Concurrent Criterion Validity, and Test-Retest Reliability of the Oxford Vaccine Hesitancy Scale. [PDF]

Vaccines (Basel)
Kantor J, Vanderslott S, Morrison M, Carlisle RC.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Predictive value of MRD monitoring by BCR clonality in the ZUMA-7 randomized clinical trial for CAR T therapy in r/r lymphoma. [PDF]

Br J Haematol
Miles B, Mao D, Vardhanabhuti S, Bedognetti D, Filosto S, Shen R.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Underlying aetiology of acute intracerebral haemorrhage and associations between outcome measures, findings on initial computed tomography scan and ICH classification systems: an observational historical cohort study. [PDF]

BMJ Open
Nielsen V, Nielsen T, Petersen SR, Andrade Melchiori F, Dreis SKR, Bitterling H, Braad PE, Stenager E, Mamoei S.   +8 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

One Assay to Rule Them All: Development of a Global Environmental DNA Tool to Support Range-Wide Surveys of an Imperiled Sawfish and Its Application in the Eastern Tropical Pacific. [PDF]

Ecol Evol
Cubillos-M JC, Fearing A, Chapman DD, Kyne PM, Dias PJ, Gonzalez C, Lehman RN, Chichaco Y, Huerta-Beltrán BL, McCulloch KL, Toepfer SM, Carlson JK, Phillips NM.   +12 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Persistent trade-offs balance competition and colonization across centuries. [PDF]

Proc Natl Acad Sci U S A
Backman T, Cui J, Caullireau E, Bleak E, Bezrukov I, Girardi P, Hawks A, Lasky JR, Latorre SM, Erberich JM, Lopez L, Neumann M, Perkins AM, Symeonidi E, Azadi P, Horvath MP, Muszyński A, Lang PLM, Karasov TL, Burbano HA.   +19 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source