Results 61 to 70 of about 87,097 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2013 The article analyzes the specificity of historical and patriotic work in the Zabaykalsky region. The focus is on the attitudes towards activities and goals of the search party “Khingan – Khalkhin-Gol” which was established in early 2012 at the Department
Drobotushenko Evgeniy Viktorovich
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Teaching the history of Italy in an Italian course as foreign language (LS)
Didattica della storia, 2020 The article presents a part of an Italian history project for foreigners who, outside Italy, study the Italian language and culture. Considering the difficulties and characteristics of the students, I propose to provide tools and knowledge useful to ...
Milena Sabato
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Competence, specificity and outsourcing: impact on the complexity of the contract [PDF]
This paper focuses on the link between the three types of specificity and the complexity of outsourcing contracts because specificity is generally considered as the most important transaction cost attribute. It also integrates external uncertainty in the
BARTHELEMY, Jerome, QUELIN, Bertrand
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Special aspects of quality management system functioning in Saratov State Medical University n.a. V.I. Razumovsky [PDF]
Саратовский научно-медицинский журнал, 2015 The article considers specificity of quality management system functioning in educational institutions and presents an overview of the historical and contemporary aspects of the quality management system's development in Saratov State Medical University ...
Bugaeva I.0. +3 more
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