Results 81 to 90 of about 87,097 (305)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

FOUNDATION OF INSTITUTIONAL FORMS OF ARTISAN TRAINING IN THE URAL REGION IN THE XVII–XVIII CENTURIES

Образование и наука, 2015
The research objective is to demonstrate the specificity of artisan training in the Ural region in the XVII–XVIII centuries, and explore the relating historical and pedagogical heritage and its implementation in the modern vocational training system ...
Andrey V. Moiseev, Andrey V. Yefanov
doaj   +1 more source

Specific Features Of Drama In The Historical And Theoretical Dimensions

, 2018
У статті розглянуто особливості формування драми як літературного жанру, автор виокремлює різновиди драми, сформовані в європейській літературі в різні періоди її розвитку. Установлено, що теоретичні основи драматизму сформульовані ще Аристотелем, модифікація особливостей драматизму відображена протягом історичного розвитку літературного процесу ...
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

THE NOTES FROM UNPUBLISHED A. PLATONOV’S NOTEBOOK: HISTORICAL-LITERARY COMMENTARY AND TEXTOLOGICAL RECONSTRUCTION

, 2019
The analysis of private archival documents about the renowned writers’ life and creative work is very acute nowadays. The article analyses previously unpublished A.

core   +1 more source

Historical stylistics of the Russian language : functional stylistics and stylistics of resources

Opera slavica, 2013
The article is devoted to the historical stylistics of the Russian language – one of the most important and promising directions of historical and linguistic research. Historical stylistics is considered in two ways: as functional stylistics that studies
Ljubov' Krylova
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Evaluation of immunoassays for the diagnosis of Schistosoma japonicum infection using archived sera. [PDF]

, 2011
BACKGROUND: With a national program initiated recently to reduce transmission of Schistosoma japonicum in the People's Republic of China (P.R. China), there is an urgent need for accessible, quality-assured diagnostics for case detection, surveillance ...
Wang Shi-Ping, Peeling, Rosanna W, Li, Hao, Wu, Zhong-Dao, Jia-Xu Chen, Xu Jing, Guo Jia-Gang, Wu Xiao-Hua, Ting Feng, Shi-Ping Wang, Jing Xu, Guo, Jia-Gang, Xiao-Hua Wu, Xiao-Nong Zhou, Jia-Gang Guo, Chen, Shao-Hong, Zhou, Xiao-Nong, Hao Li, Wang, Shi-Ping, Chen Shao-Hong, Wu, Xiao-Hua, Peeling Rosanna W., Zhou Xiao-Nong, Feng, Ting, Chen Jia-Xu, Xu, Jing, Chen, Jia-Xu, Li Hao, Rosanna W. Peeling, Wu Zhong-Dao, Rosanna W Peeling, Zhong-Dao Wu, Shao-Hong Chen, Feng Ting   +33 more
core   +1 more source

Formulating and evaluating time series algorithms to forecast daily asthma hospital admissions

Journal of Clinical and Translational Science
Introduction: Asthma exacerbations are frequent causes of pediatric hospital admissions. We sought to develop a time series algorithm to forecast next-day daily asthma hospitalizations.
Stephen P. Colegate, Michael Seid, David Hartley, Aaron Flicker, Joseph Bruce, Joseph Michael, Mfonobong Udoko, Andrew F. Beck, Cole Brokamp   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source