Results 91 to 100 of about 12,078,524 (337)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

[Review of] Werner Sollors, cd. The Invention of Ethnicity [PDF]

, 1992
The Invention of Ethnicity is obviously and admittedly shaped after Hobsbawm\u27s and Ranger\u27s Invention of Tradition, published in 1986, when the essays in this volume were finished. In the meantime, much of what Sollors argues for in his editor\u27s
Isernhagen, Hartwig
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Language for Specific Purposes Testing: A Historical Review

Working Papers in Applied Linguistics and TESOL, 2017
Language for specific purposes (LSP) has a long history in the language testing literature. An outgrowth of the communicative language movement of the 1970s, LSP testing arose out of the practical need to assess individuals’ abilities to perform specific tasks in academic and professional settings.
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

FOUNDATION OF INSTITUTIONAL FORMS OF ARTISAN TRAINING IN THE URAL REGION IN THE XVII–XVIII CENTURIES

Образование и наука, 2015
The research objective is to demonstrate the specificity of artisan training in the Ural region in the XVII–XVIII centuries, and explore the relating historical and pedagogical heritage and its implementation in the modern vocational training system ...
Andrey V. Moiseev, Andrey V. Yefanov
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Historical stylistics of the Russian language : functional stylistics and stylistics of resources

Opera slavica, 2013
The article is devoted to the historical stylistics of the Russian language – one of the most important and promising directions of historical and linguistic research. Historical stylistics is considered in two ways: as functional stylistics that studies
Ljubov' Krylova
doaj  

Sense-specific Historical Word Usage Generation

Transactions of the Association for Computational Linguistics
Abstract Large-scale sense-annotated corpora are important for a range of tasks but are hard to come by. Dictionaries that record and describe the vocabulary of a language often offer a small set of real-world example sentences for each sense of a word.
Pierluigi Cassotti, Nina Tahmasebi
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source