Results 111 to 120 of about 87,097 (305)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Ivan Shamyakin’s Prose of the 1970’s: Genre and Stylistic Specificity, Distinct (Specific) Historical and Axiological Content

, 2019
The evolution of Ivan Shamyakin‟s creativity in the 1970‟s is expressed in this article. The genre and stylistic specificity of such stories as «Wedding Night», «Merchant and poet», of the novel «I‟ll take your pain» are highlighted.
Кавалюк, А. С.
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Specificity of formation and development of traditional musical culture in the Kemerovo region territory

, 2019
The timeliness of the article is determined by identifying general and specific characteristics of formation and existence of musical culture in the industrially developed region of Siberia, which preserves diversity of musical traditions. The goal is to
Egle, Lyudmila Yu., Ryabtseva, Vaselina A., Markov, Victor I.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Regional specificity in the formation and development of the historical geography of Ukraine in the 19th – early 20th centuries

, 2022
У роботі розглянуто процес становлення історичної географії України в університетах Києва, Харкова, Одеси та Львова у ХІХ – початку ХХ ст. як навчальної дисципліни; охарактеризовано роль наукових осередків (товариств, відділень тощо) України у формуванні
Ivasiuk (Nikichuk), Viktoriia S., Івасюк (Нікічук), Вікторія Сергіївна   +1 more
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Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The anthroponyme of the border zone: adaptive processes and the specificity of crosscultural contacts

, 2012
Юлия Галковская, ВитебскThe article deals with the description of dynamic peculiarities in the name system of Lyntupy situated in the western border part of Vitebsk region under existing conditions of close historical and cultural contacts with adjoining
Gałkowskaja, Julia
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Byzantian Hagiographyasa Historical Source: Historiography of the Problem

, 2005
The article is devoted to the historiographie works on the specificity of the Byzantian hagiography as a historical source. There is no uniform opinion about the value of hagiographie texts as historical sources in modern historiography, so we shall ...
Мінець, Юлія
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