Results 41 to 50 of about 835,368 (300)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

User Collaboration for Improving Access to Historical Texts

open access: yesLiber Quarterly: The Journal of European Research Libraries, 2010
The paper will describe how web-based collaboration tools can engage users in the building of historical printed text resources created by mass digitisation projects.
Clemens Neudecker, Asaf Tzadok
doaj   +1 more source

Early Carthusian Script and Silence [PDF]

open access: yes, 2014
At its founding and during its first three decades, the Carthusian order developed a distinctive and forceful concept of communication among the members and between the members and the extramural world.2 Saint Bruno’s life ...
Gilbert, Bennett
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Examining trends in epidemic typhus using historical texts

open access: yesJournal of Vector Borne Diseases
Background & objectives: Although associated with conflict, epidemic typhus was endemic across Europe into the modem period. The extent of the problem it caused is uncertain as record keeping in the most affected socioeconomic groups was rare.
Mark David Walker
doaj   +1 more source

How Does Science Come to Speak in the Courts? Citations Intertexts, Expert Witnesses, Consequential Facts, and Reasoning [PDF]

open access: yes, 2009
Citations, in their highly conventionalized forms, visibly indicate each texts explicit use of the prior literature that embodies the knowledge and contentions of its field.
Bazerman, Charles
core   +1 more source

Digital Presentation of Bulgarian Lexical Heritage. Towards an Electronic Historical Dictionary [PDF]

open access: yes, 2012
The article presents the results of the project “ICT Tools for Historical Linguistic Studies”, funded by the European Social Fund, OP Human Resources.
Totomanova, Anna-Maria
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Interpreting and Explaining Historical Texts – Is it Possible?

open access: yesNordicom Review, 2006
With reference to particular problems of interpretations that radio listeners of today are likely to encounter when listening to a Norwegian radio reportage from the 1930s, this article discusses the question of whether it is possible for present-day ...
Vagle Wenche
doaj   +1 more source

Reading Matthew as a historical narrative

open access: yesIn die Skriflig, 2018
The grammatico-historical method of Bible interpretation is often used in traditional reformed hermeneutics and is usually defined as distinctive from historical and reader-response criticism.
Francois P. Viljoen
doaj   +1 more source

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